Results 11 to 20 of about 21,311 (187)
Protein disulfide isomerase in cardiovascular disease [PDF]
Experimental and Molecular Medicine, 2020 Exploring enzymes’ influence on cardiovascular disease Efforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases.
Bei Xiong +3 more
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Compact conformations of human protein disulfide isomerase. [PDF]
PLoS ONE, 2014 Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum.
Shang Yang +8 more
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Protein Disulfide Isomerase and Host-Pathogen Interaction [PDF]
The Scientific World Journal, 2011 Reactive oxygen species (ROS) production by immunological cells is known to cause damage to pathogens. Increasing evidence accumulated in the last decade has shown, however, that ROS (and redox signals) functionally regulate different cellular pathways ...
Beatriz S. Stolf +7 more
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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent [PDF]
mBioThe protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities.
Xiaotian Tang +5 more
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Protein disulfide isomerase A3 as novel biomarker for endometrial cancer [PDF]
Frontiers in Oncology, 2023 ObjectiveThis study aims to investigate the potential of PDIA3 as a novel prognostic biomarker and therapeutic target for Endometrial Cancer (EC) with the ultimate goal of improving survival rates in EC patients.MethodsThis study employed a combination ...
Fanrong Yu +6 more
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Protein disulfide isomerase is essential for osteoblast differentiation in mice [PDF]
Communications BiologyProtein disulfide isomerase (PDI) is an oxidoreductase responsible for the formation, reduction and isomerization of disulfide bonds of nascent proteins in endoplasmic reticulum (ER).
Yue Lu +5 more
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The human protein disulfide isomerase gene family [PDF]
Human Genomics, 2012 Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of proteins known ...
Galligan James J, Petersen Dennis R
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Protein disulfide isomerase is essential for spermatogenesis in mice [PDF]
JCI InsightSpermatogenesis requires precise posttranslational control in the endoplasmic reticulum (ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) family is a group of thiol oxidoreductases responsible for catalyzing the ...
Yaqiong Zhang +7 more
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Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204 [PDF]
Frontiers in PhysiologyRedox processes can modulate vascular pathophysiology. The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress ...
Leonardo Y. Tanaka +7 more
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Autodegradation of Protein Disulfide Isomerase [PDF]
Bioscience, Biotechnology, and Biochemistry, 1999 Protein disulfide isomerase (PDI) and its degradation products were found in HepG2, COS-1, and CHO-K1 cells. Whether or not the products were formed through autodegradation of PDI was examined, since PDI contains the CGHC motif, which is the active center of proteolytic activity in ER-60 protease.
R, Urade +4 more
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