Results 71 to 80 of about 83,411 (273)

The role and mechanism of TXNDC5 in disease progression

Frontiers in Immunology
Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI ...
Mingxia Jiao, Mingxia Jiao, Yeyong Zhang, Xie Song, Xie Song, Bing Xu, Bing Xu   +6 more
doaj   +1 more source

Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry

Viruses, 2020
Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8
Nayeli Aguilar-Hernández, Lena Meyer, Susana López, Rebecca M. DuBois, Carlos F. Arias   +4 more
doaj   +1 more source

Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.

Biochemistry, 2018
Protein disulfide isomerase A1 (PDIA1) is an endoplasmic reticulum (ER)-localized thiol-disulfide oxidoreductase that is an important folding catalyst for secretory pathway proteins.
Kyle S. Cole, Julia M. Grandjean, Kenny Chen, Collin H. Witt, Johanna O'Day, M. Shoulders, R. L. Wiseman, E. Weerapana   +7 more
semanticscholar   +1 more source

Functional Differences in Yeast Protein Disulfide Isomerases [PDF]

The Journal of Cell Biology, 2001
PDI1 is the essential gene encoding protein disulfide isomerase in yeast. The Saccharomyces cerevisiae genome, however, contains four other nonessential genes with homology to PDI1: MPD1, MPD2, EUG1, and EPS1. We have investigated the effects of simultaneous deletions of these genes. In several cases, we found that the ability of the PDI1 homologues to
Jakob R. Winther, Lene Alsøe, Vibeke Westphal, Christine Tachibana, Bjørn Holst, Per Nørgaard   +5 more
openaire   +3 more sources

EXPRESSION OF ENDOPLASMIC RETICULUM OXIDOREDUCTASES (EROS) AND THEIR ROLE IN THE GI TRACT [PDF]

, 2012
It has been shown that some ER redox enzymes are differentially expressed in stomach and oesophagus tissue. The tissues of the gastrointestinal system, which are subject to external changes of environment during the process of digestion, represent a ...
WATSON, GRAEME
core  

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Protein Profiling of Arabidopsis Roots Treated With Humic Substances: Insights Into the Metabolic and Interactome Networks [PDF]

, 2018
Background and Aim: Humic substances (HSs) influence the chemical and physical properties of the soil, and are also known to affect plant physiology and nutrient uptake.
Antonio Masi, Giorgio Arrigoni, Giorgio Arrigoni, Giovanni Battista Conselvan, Micaela Pivato, Paolo Carletti, Sara Trevisan, Silvia Quaggiotti, Sohaib Roomi, Tayyaba Yasmin   +9 more
core   +4 more sources

Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation.

JCI Insight, 2017
BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation. We previously demonstrated that glycosylated quercetin flavonoids such as isoquercetin inhibit PDI activity and thrombus formation in animal models, but whether ...
Jack D. Stopa, D. Neuberg, M. Puligandla, B. Furie, R. Flaumenhaft, J. Zwicker   +5 more
semanticscholar   +1 more source

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]

, 2006
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S., Davydov, Ilia V., Hu, Rong-Gui, Kwon, Yong Tae, Sheng, Jun, Varshavsky, Alexander, Wang, Haiqing, Zhou, Jianmin   +7 more
core   +2 more sources

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

Journal of Thrombosis and Haemostasis, 2018
Essentials Nitric oxide synthesis controls protein disulfide isomerase (PDI) function. Nitric oxide (NO) modulation of PDI controls endothelial thrombogenicity. S‐nitrosylated PDI inhibits platelet function and thrombosis. Nitric oxide maintains vascular
Roelof H. Bekendam, Roelof H. Bekendam, D. Iyu, D. Iyu, F. Passam, Jack D. Stopa, K. D. Ceunynck, Oluwatoyosi Muse, Pavan K. Bendapudi, C. L. Garnier, Srila Gopal, L. Crescence, Joyce Chiu, Bruce Furie, L. Panicot-Dubois, Philip J Hogg, C. Dubois, R. Flaumenhaft   +17 more
semanticscholar   +1 more source