Results 201 to 210 of about 16,988,925 (342)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Label-Free Single Protein Dynamics Revealed by Metasurface-Enhanced Raman Spectroscopy. [PDF]

ACS Nano
Aghdaee M, Zaidouni S, Bahiraie Y, Kumari A, Ojambati OS.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

3D Protein Dynamics in the Cell Nucleus.

Biophysical Journal, 2017
Anand Singh, R. Galland, M. Finch-Edmondson, G. Grenci, J. Sibarita, V. Studer, V. Viasnoff, T. Saunders   +7 more
semanticscholar   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

General Dynamics News

, 1966
Biweekly newsletter published for employees of the General Dynamics Fort Worth Division containing work-related information, updates about employees, and other ...
General Dynamics Corporation. Convair Division.
core  

Capping protein dynamics are defined by the stalk and restricted by CPI-motif and V-1 binding. [PDF]

Biophys J
Yan C, Sept D.
europepmc   +1 more source

Protein dynamics and function from solution state NMR spectroscopy

Quarterly Reviews of Biophysics (print), 2016
M. Kovermann, P. Rogne, M. Wolf-Watz
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells. [PDF]

Adv Mater
Locarno M, Dong Q, Post M, Meng X, Glessi C, Hettema NM, Brandsma N, Blokhuizen S, Castañeda Garcia A, Ganapathy S, Schmidt T, van Roemburg L, Xu B, Cho CT, Laan L, Chien MP, Brinks D.   +16 more
europepmc   +1 more source