Results 181 to 190 of about 1,281,585 (240)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion. [PDF]

Chembiochem
Guo Y, Cheng L, Hu Y, Zhang M, Liu R, Wang Y, Jiang S, Xiao H.   +7 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Beyond small molecules: advancing MYC-targeted cancer therapies through protein engineering. [PDF]

Transcription
Edaibis R, Akel R, Shin JA.
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

A systematic analysis of regression models for protein engineering. [PDF]

PLoS Comput Biol
Michael R, Kæstel-Hansen J, Mørch Groth P, Bartels S, Salomon J, Tian P, Hatzakis NS, Boomsma W.   +7 more
europepmc   +1 more source

Metabolic reprogramming and computation-aided protein engineering for high-level de novo biosynthesis for 2-phenylethanol in <i>Pichia pastoris</i>. [PDF]

Synth Syst Biotechnol
Sun L, Liu S, Sun R, Li J, Yu A, Wong A, Lin L, Zhang C.   +7 more
europepmc   +1 more source

The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme. [PDF]

Toxins (Basel)
Dotsenko A, Sinelnikov I, Zorov I, Denisenko Y, Rozhkova A, Shcherbakova L.   +5 more
europepmc   +1 more source

Unifying sequence-structure coding for advanced protein engineering <i>via</i> a multimodal diffusion transformer. [PDF]

Chem Sci
Lin X, Chen Z, Li Y, Ma Z, Fan C, Cao Z, Feng S, Zhang J, Gao YQ.   +8 more
europepmc   +1 more source

New advances in protein engineering for industrial applications: Key takeaways. [PDF]

Open Life Sci
Ndochinwa GO, Wang QY, Okoro NO, Amadi OC, Nwagu TN, Nnamchi CI, Moneke AN, Odiba AS.   +7 more
europepmc   +1 more source