Results 201 to 210 of about 8,703,040 (401)

De Novo Functional Protein Sequence Generation: Overcoming Data Scarcity through Regeneration and Large Models [PDF]

arXiv
Proteins are essential components of all living organisms and play a critical role in cellular survival. They have a broad range of applications, from clinical treatments to material engineering. This versatility has spurred the development of protein design, with amino acid sequence design being a crucial step in the process.
arxiv  

Mutexa: A Computational Ecosystem for Intelligent Protein Engineering. [PDF]

J Chem Theory Comput, 2023
Yang ZJ, Shao Q, Jiang Y, Jurich C, Ran X, Juarez RJ, Yan B, Stull SL, Gollu A, Ding N.   +9 more
europepmc   +1 more source

Protein engineering as a tool for crystallography [PDF]

, 1995
Stephen R. Price, Kiyoshi Nagai
openalex   +1 more source

Protein Engineering for Improving and Diversifying Natural Product Biosynthesis.

Trends in Biotechnology, 2020
Chenyi Li, Ruihua Zhang, Jian Wang, L. M. Wilson, Yajun Yan   +4 more
semanticscholar   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Leveraging Multi-modal Representations to Predict Protein Melting Temperatures [PDF]

arXiv
Accurately predicting protein melting temperature changes (Delta Tm) is fundamental for assessing protein stability and guiding protein engineering. Leveraging multi-modal protein representations has shown great promise in capturing the complex relationships among protein sequences, structures, and functions.
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Protein engineering

Current Opinion in Biotechnology, 1996
, de Vos AM, , Plückthun
openaire   +3 more sources

ACIDES: on-line monitoring of forward genetic screens for protein engineering. [PDF]

Nat Commun, 2023
Nemoto T, Ocari T, Planul A, Tekinsoy M, Zin EA, Dalkara D, Ferrari U.   +6 more
europepmc   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source