Results 201 to 210 of about 8,269,032 (242)
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2007
This chapter focuses on protein engineering strategies that aim to increase the chances of obtaining crystals suitable for X-ray diffraction. The chapter is divided into three main parts: one dealing with protein engineering through a bioinformatics approach, the second focusing on DNA modifications via random mutagenesis, and the third describing a ...
Sonia, Longhi +2 more
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This chapter focuses on protein engineering strategies that aim to increase the chances of obtaining crystals suitable for X-ray diffraction. The chapter is divided into three main parts: one dealing with protein engineering through a bioinformatics approach, the second focusing on DNA modifications via random mutagenesis, and the third describing a ...
Sonia, Longhi +2 more
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Protein engineering of lantibiotics
Antonie van Leeuwenhoek, 1996Whereas protein engineering of enzymes and structural proteins nowadays is an established research tool for studying structure-function relationships of polypeptides and for improving their properties, the engineering of posttranslationally modified peptides, such as the lantibiotics, is just coming of age.
Kuipers, O.P. +17 more
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Science, 1983
The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modeling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene ...
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The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modeling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene ...
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Trends in Biotechnology, 1997
Membrane proteins perform many of the essential functions required for life. They are often the targets of medicinal drugs and have many potential uses in biotechnological processes. Therefore our ability to understand them and manipulate their functions is both important and necessary to enable protein engineers to create 'designer' membrane proteins (
G. von Heijne +2 more
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Membrane proteins perform many of the essential functions required for life. They are often the targets of medicinal drugs and have many potential uses in biotechnological processes. Therefore our ability to understand them and manipulate their functions is both important and necessary to enable protein engineers to create 'designer' membrane proteins (
G. von Heijne +2 more
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Engineering therapeutic proteins
Current Opinion in Structural Biology, 2000Many early drug candidates derived from biotechnology failed in clinical trials because of their low affinity/specificity, short half-lives or immunogenicity. Protein engineering techniques have been applied to circumvent some of the problems that hindered these earlier trials, resulting in clinical benefits from a range of engineered antibodies and ...
John McCafferty, David R Glover
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Engineered Proteins for Bioelectrochemistry
Annual Review of Analytical Chemistry, 2014It is only in the past two decades that excellent protein engineering tools have begun to meet parallel advances in materials chemistry, nanofabrication, and electronics. This is revealing scenarios from which synthetic enzymes can emerge, which were previously impossible, as well as interfaces with novel electrode materials. That means the control of
Jawad Ur Rehman +2 more
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Biotechnology Advances, 1987
The techniques of protein engineering are proving to be a revolutionary experimental tool for understanding protein structure-function relationships. Even at this early stage, proteins of improved characteristics for specific industrial and therapeutic uses have already been produced.
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The techniques of protein engineering are proving to be a revolutionary experimental tool for understanding protein structure-function relationships. Even at this early stage, proteins of improved characteristics for specific industrial and therapeutic uses have already been produced.
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2009
A variety of enzymes have been in industrial use since before genetic engineering appeared. However, a mere couple of dozen enzymes account for over 90% of total industrial enzyme use. Some common examples are listed in this chapter. These proteins are used under relatively harsh conditions and are exposed to oxidizing conditions not found inside ...
David P. Clark, Nanette J. Pazdernik
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A variety of enzymes have been in industrial use since before genetic engineering appeared. However, a mere couple of dozen enzymes account for over 90% of total industrial enzyme use. Some common examples are listed in this chapter. These proteins are used under relatively harsh conditions and are exposed to oxidizing conditions not found inside ...
David P. Clark, Nanette J. Pazdernik
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Current Trends in Protein Engineering: Updates and Progress.
Current protein and peptide science, 2019Proteins are one of the most important and resourceful biomolecules that find applications in health, industry, medicine, research, and biotechnology.
R. Sinha, Pratyoosh Shukla
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Protein engineering of rubisco
Acta Crystallographica Section B Structural Science, 1991Modification of the kinetic parameters of enzymes by protein engineering requires extensive knowledge of the structural details of the enzyme and its complexes with different reaction intermediate analogues. Such structural studies are described here for Rubisco, ribulose-1,5-bisphosphate carboxylase/oxygenase, which catalyzes the initial reactions of ...
C I Brändén +2 more
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