Results 241 to 250 of about 8,703,040 (401)

Protein engineering in the deep learning era. [PDF]

mLife
Zhou B, Tan Y, Hu Y, Zheng L, Zhong B, Hong L.   +5 more
europepmc   +1 more source

Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein [PDF]

, 2001
Henrik Østergaard, A. Henriksen, Flemming Hansen, Jakob R. Winther   +3 more
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

An update on thermostable keratinases for protein engineering against feather pollutants. [PDF]

Appl Microbiol Biotechnol
J L BJ, Dhanasingh I.
europepmc   +1 more source

Molecular analysis of the type III interferon complex and its applications in protein engineering. [PDF]

Biophys J, 2023
Grubbe WS, Byléhn F, Alvarado W, de Pablo JJ, Mendoza JL.   +4 more
europepmc   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

A suite of pre-assembled, pET28b-based Golden Gate vectors for efficient protein engineering and expression. [PDF]

Protein Sci
Gaur D, Wohlever ML.
europepmc   +1 more source

Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin.

, 1995
Roman Drews, Rekha K. Paleyanda, Timothy K. Lee, Rudy Chang, Alnawaz Rehemtulla, Randal J. Kaufman, William N. Drohan, Henryk Luboń   +7 more
openalex   +1 more source

Engineering Δ9-16:0-Acyl Carrier Protein (ACP) Desaturase Specificity Based on Combinatorial Saturation Mutagenesis and Logical Redesign of the Castor Δ9-18:0-ACP Desaturase [PDF]

, 2001
Edward Whittle, John Shanklin
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source