Results 31 to 40 of about 8,269,032 (242)
Versatile and rapid microfluidics-assisted antibody discovery
mAbs, 2021 Recent years have seen unparalleled development of microfluidic applications for antibody discovery in both academic and pharmaceutical research. Microfluidics can support native chain-paired library generation as well as direct screening of antibody ...
Ramona Gaa +5 more
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A Deep Dive into Machine Learning Models for Protein Engineering.
Journal of Chemical Information and Modeling, 2020 Protein redesign and engineering has become an important task in pharmaceutical research and development. Recent advances in technology have enabled efficient protein redesign by mimicking natural evolutionary mutation, selection and amplification steps ...
Yuting Xu +9 more
semanticscholar +1 more source
Solid-phase synthesis of protein-polymers on reversible immobilization supports
Nature Communications, 2018 Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins ...
Hironobu Murata +4 more
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mAbs, 2020 The ability to genetically encode non-natural amino acids (nnAAs) into proteins offers an expanded tool set for protein engineering. nnAAs containing unique functional moieties have enabled the study of post-translational modifications, protein ...
Gargi Roy +11 more
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Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice
Biomolecules, 2021 Improvement of longevity is an eternal dream of human beings. The accumulation of protein damages is considered as a major cause of aging. Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of
Jiaze Tang +9 more
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Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis
Scientific Reports, 2023 The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX inhibits cellular p53 activity, which is highly relevant to cancer occurrence. Coiled-coil
Ting Zhou +7 more
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Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond
Pharmacological Reviews, 2020 Ubiquitin (UB) transfer cascades consisting of E1, E2, and E3 enzymes constitute a complex network that regulates a myriad of biologic processes by modifying protein substrates.
Bo Zhao +8 more
semanticscholar +1 more source
Nature Communications, 2022 Peptide fragments derived from the interfaces of protein-protein interactions (PPIs) provide useful templates for designing small molecule PPI inhibitors.
Xiyao Cheng +8 more
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ACS Catalysis, 2020 Unspecific peroxygenases (UPOs) enable oxyfunctionalizations of a broad substrate range with unparalleled activities. Tailoring these enzymes for chemo- and regioselective transformations represents a grand challenge due to the difficulties in their ...
Anja Knorrscheidt +5 more
semanticscholar +1 more source
FEBS Letters, 2013 Improving the stability of proteins is an important goal in many biomedical and industrial applications. A logical approach is to emulate stabilizing molecular interactions found in nature. Disulfide bonds are covalent interactions that provide substantial stability to many proteins and conform to well‐defined geometric conformations, thus making them ...
Douglas B. Craig +2 more
openaire +3 more sources