Results 51 to 60 of about 8,269,032 (242)

Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.

Journal of the American Chemical Society, 2019
Enzymatic stereodivergent synthesis to access all possible product stereoisomers bearing multiple stereocenters is relatively undeveloped, although enzymes are being increasingly used in both academic and industrial areas. When two stereocenters and thus
Jian Xu, Y. Cen, Warispreet Singh, Jiajie Fan, Lian Wu, Xianfu Lin, Jiahai Zhou, Meilan Huang, M. Reetz, Qi Wu   +9 more
semanticscholar   +1 more source

Synthesis of Human Milk Oligosaccharides: Protein Engineering Strategies for Improved Enzymatic Transglycosylation

Molecules, 2019
Human milk oligosaccharides (HMOs) signify a unique group of oligosaccharides in breast milk, which is of major importance for infant health and development.
Birgitte Zeuner, D. Tezé, Jan Muschiol, A. Meyer   +3 more
semanticscholar   +1 more source

Identification of a peptide antagonist of the FGF1–FGFR1 signaling axis by phage display selection

FEBS Open Bio, 2019
Overexpression of fibroblast growth factor receptor 1 (FGFR1) is a common aberration in lung and breast cancers and has necessitated the design of drugs targeting FGFR1‐dependent downstream signaling and FGFR1 ligand binding.
Magdalena Lipok, Anna Szlachcic, Kinga Kindela, Aleksandra Czyrek, Jacek Otlewski   +4 more
doaj   +1 more source

Protein engineering expands the effector recognition profile of a rice NLR immune receptor

bioRxiv, 2019
Plant NLR receptors detect pathogen effectors and initiate an immune response. Since their discovery, NLRs have been the focus of protein engineering to improve disease resistance.
J.C. De la Concepcion, M. Franceschetti, D. MacLean, R. Terauchi, S. Kamoun, M. Banfield   +5 more
semanticscholar   +1 more source

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner

Cells, 2020
Metformin has been documented in epidemiological studies to mitigate tumor progression. Previous reports show that metformin inhibits tumor migration in several cell lines, such as MCF-7 and H1299, but the mechanisms whereby metformin exerts its ...
Yuanchao Gong, Caihong Wang, Yi Jiang, Shaosen Zhang, Shi Feng, Yan Fu, Yongzhang Luo   +6 more
doaj   +1 more source

Transposon for protein engineering [PDF]

Mobile Genetic Elements, 2016
Protein insertional fusion and circular permutation are 2 promising protein engineering techniques for creating integrated functionalities and sequence diversity of a protein, respectively. Finding insertion locations for protein insertional fusion and new termini for circular permutation through a rational approach is not always straightforward ...
Jin Ryoun Kim, Vandan Shah
openaire   +3 more sources

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

mAbs, 2020
Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the ...
Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall’Acqua, Yariv Mazor   +6 more
doaj   +1 more source

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Molecular Oncology, 2020
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death.
Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski   +9 more
doaj   +1 more source

Droplet Microfluidics-Enabled High-Throughput Screening for Protein Engineering

Micromachines, 2019
Protein engineering—the process of developing useful or valuable proteins—has successfully created a wide range of proteins tailored to specific agricultural, industrial, and biomedical applications.
Lindong Weng, J. Spoonamore
semanticscholar   +1 more source

Engineering Nutritious Proteins [PDF]

Biotechnology and Genetic Engineering Reviews, 1997
(1997). Engineering Nutritious Proteins. Biotechnology and Genetic Engineering Reviews: Vol. 14, No. 1, pp. 191-210.
openaire   +3 more sources