Results 131 to 140 of about 6,490,832 (265)

Outer membrane protein evolution. [PDF]

Curr Opin Struct Biol, 2021
Dhar R, Slusky JS.
europepmc   +1 more source

Epistasis plays a limited role in driving entrenchment during neutral protein evolution. [PDF]

Genome Biol
Schmelkin L, Chung S, Haldane A, Townsend JP, Carnevale V, Levy RM, Kumar S.   +6 more
europepmc   +1 more source

Phenotypic mutations contribute to protein diversity and shape protein evolution. [PDF]

Protein Sci, 2022
Romero Romero ML, Landerer C, Poehls J, Toth-Petroczy A.   +3 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Epistatic drift in protein evolution. [PDF]

Curr Opin Genet Dev
Muñiz-Trejo R, Patton JE, Herrera-Álvarez S, Thornton JW.   +3 more
europepmc   +1 more source

Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution. [PDF]

Sci Adv, 2023
Kiefl E, Esen OC, Miller SE, Kroll KL, Willis AD, Rappé MS, Pan T, Eren AM.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Sequence Display enables large-scale sequence-activity datasets for rapid protein evolution. [PDF]

Nat Biotechnol
Cheng L, Zheng X, Jiang SJ, Hu Y, Liu Y, Yang K, Rui J, Ding H, Zhang M, Yuan T, Lu Q, Ye H, Li CL, Guo Y, Tian Z, Qin A, Zhou B, Yang KK, Huang X, Xiao H.   +19 more
europepmc   +1 more source

In vivo client proteins of the chaperonin GroEL-GroES provide insight into the role of chaperones in protein evolution. [PDF]

Front Mol Biosci, 2023
Taguchi H, Koike-Takeshita A.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source