Results 141 to 150 of about 6,490,832 (265)

Deep Prior Framework: integrating functional specificity with general plausibility for targeted protein evolution. [PDF]

Brief Bioinform
Zhang S, Qin Y, Zhu H, Meng F, Jia L, Zheng X.   +5 more
europepmc   +1 more source

Epistatic drift causes gradual decay of predictability in protein evolution. [PDF]

Science, 2022
Park Y, Metzger BPH, Thornton JW.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Bryophyte Transcription Factor Landscape Reveals Lineage-Specific Zinc-Finger Protein Evolution and Differential Stress Mobilization Between Mosses and Liverworts. [PDF]

Plants (Basel)
He X, Leng F, Yan S, Hu Y, He Y.
europepmc   +1 more source

Shared Patterns of Gene Expression and Protein Evolution Associated with Adaptation to Desert Environments in Rodents. [PDF]

Genome Biol Evol, 2022
Bittner NKJ, Mack KL, Nachman MW.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Tail spike protein evolution enables phage Psm140 to target Salmonella ShdA and overcome host resistance. [PDF]

Poult Sci
Zeng Y, Han S, Wan X, Lin Z, Duan X, Zhou X, Zhang G, Shen J.   +7 more
europepmc   +1 more source

A Mutation-Selection Model of Protein Evolution under Persistent Positive Selection. [PDF]

Mol Biol Evol, 2022
Tamuri AU, Dos Reis M.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Targeted protein evolution in the gut microbiome by diversity-generating retroelements. [PDF]

Science
Macadangdang BR, Wang Y, Woodward CL, Revilla JI, Shaw BM, Sasaninia K, Varnum GE, Makanani SK, Berruto C, Ahuja U, Miller JF.   +10 more
europepmc   +1 more source