Results 151 to 160 of about 6,490,832 (265)

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates. [PDF]

PLoS Comput Biol, 2023
Norn C, André I.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An iterative deep learning-guided algorithm for directed protein evolution. [PDF]

iScience
Li X, Wang Q, Li J, Tang F, Yang X, Lin Z.   +5 more
europepmc   +1 more source

Pairs of Mutually Compensatory Frameshifting Mutations Contribute to Protein Evolution. [PDF]

Mol Biol Evol, 2022
Biba D, Klink G, Bazykin GA.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Ancestral Chaperonins Provide the First Structural Glimpse into Early Multimeric Protein Evolution. [PDF]

Mol Biol Evol
Severino R, Cuéllar J, Gutiérrez-Seijo J, Maestro-López M, Sánchez-Pulido L, Santiago C, Moreno-Paz M, Valpuesta JM, Parro V.   +8 more
europepmc   +1 more source

Influence of Zika virus 3'-end sequence and nonstructural protein evolution on the viral replication competence and virulence. [PDF]

Emerg Microbes Infect, 2022
Jung HG, Cho H, Kim M, Jung H, Bak Y, Lee SY, Seo HY, Son YM, Woo H, Yoon G, Kim SJ, Oh JW.   +11 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Protein evolution [PDF]

Nature, 1982
openaire   +1 more source

Anticipating protein evolution with successor sequence predictor. [PDF]

J Cheminform
Khan RT, Kohout P, Musil M, Rosinska M, Damborsky J, Mazurenko S, Bednar D.   +6 more
europepmc   +1 more source