Results 131 to 140 of about 29,093 (266)

Targeting the Ubiquitin-Proteasome System in Atrial Fibrillation: Mechanistic Insights and Translational Perspectives. [PDF]

Curr Issues Mol Biol
Huang R, Pu Z, Chen Z.
europepmc   +1 more source

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Advancements in research on the cardiovascular toxicity caused by TEC family kinases inhibitors. [PDF]

Front Pharmacol
Zhang Y, Fu H, Kang X, Qiu Z, Yan H, He Q, Yang B, Xu Z, Luo P.   +8 more
europepmc   +1 more source

Exploration of the Role of Cilostazol in Brugada Syndrome: Mechanisms, Therapeutic Potential, and Implications in the Prevention of Ventricular Arrhythmias. [PDF]

Rev Cardiovasc Med
Iqbal M, Putra ICS, Karwiky G, Achmad C.
europepmc   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models. [PDF]

Signal Transduct Target Ther
Xiong K, Wang G, Li D, Shao B, Chen Z, Zou Q, Zhang X, Dong Y, Zhao X, Yuan Y, Xu H, Liu Y, Liang D, Wang L, Zhou B, Dong N, Xie D, Chen YH.   +17 more
europepmc   +1 more source

Inflammatory and fibrotic signaling pathways mediated by cardiac macrophages in atrial fibrillation. [PDF]

Front Cardiovasc Med
Ren H, Lai H, Chen Z.
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Glucose metabolic dysregulation of diabetes and Its role in atrial fibrillation pathogenesis. [PDF]

Front Cardiovasc Med
Chen Y, Xu M, Wei K, Ma N.
europepmc   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source