Results 141 to 150 of about 4,544,497 (292)

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins

Cardiology Journal
This study aimed to employ Mendelian randomization (MR) analysis to investigate the causal relationship between sodium-glucose cotransporter 2 (SGLT2) inhibition and atrial fibrillation (AF), as well as assess the potential mediating role of inflammatory proteins in this association.A two-sample MR analysis was conducted using summary-level data from ...
Yi, Chengcheng, Zheng, Wenyuan, Wang, Junqian, Li, Wenqiang, Zhang, Yiming, Zhou, Dan, Lei, Peng, Wang, Yongxiang, Bai, Ming, Zhang, Zheng   +9 more
openaire   +3 more sources

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins

Neurotherapeutics
Alzheimer's disease (AD) pathology involves amyloid-beta (Aβ) accumulation and neuronal toxicity, highlighting the need for therapeutic strategies that can both inhibit Aβ aggregation and promote pathogenic protein clearance. In this study, we identified Gaultheria leucocarpa as a medicinal plant with promising neuroprotective potential.
Zhang, Yue, Deng, Lan, Wei, Jing, Huang, Lufen, Gao, Fei, Yu, Lu, Zhu, Fengdan, Mi, Jianing, Wu, Jianming, Ren, Fang, Guo, Minsong, Zhou, Xiaogang, Qin, Dalian, Chen, Ting, Wu, Anguo   +14 more
openaire   +2 more sources

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Inhibition of Amyloid Fibril Growth by Nanoparticle Coated with Histidine-Based Polymer

, 2016
Amyloid protein fibrillation is responsible for variety of neurological disorders and thus inhibition of fibrillation is a potential therapeutic strategy for these diseases.
Nihar R. Jana (207864), Nikhil R. Jana (1268586), Sharbari Palmal (1748968)   +2 more
core   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Many cardiomyopathy‐associated FLNC pathogenic variants are heterozygous truncations, and FLNC pathogenic variants are associated with arrhythmias. Arrhythmia triggers in filaminopathy are incompletely understood.
Joyce C. Ohiri, Lisa Dellefave‐Castillo, Garima Tomar, Lisa Wilsbacher, Lubna Choudhury, David Y. Barefield, Dominic Fullenkamp, Anthony M. Gacita, Tanner O. Monroe, Lorenzo Pesce, Malorie Blancard, Lauren Vaught, Alfred L. George, Alexis R. Demonbreun, Megan J. Puckelwartz, Elizabeth M. McNally   +15 more
doaj   +1 more source

Chemistry Underlying the Behavior of Food and Agricultural Components During Industrial Manufacturing Processes and Its Implications in Quality Assurance, Food Quality, and Food Safety Management: A Systematic Review

Food Safety and Health, EarlyView.
Industrial manufacturing processes have transformative effects on the components of food matrix. These transformations in food matrix and components have direct implications for quality assurance (QA), food quality (e.g., nutritional profile and texture), and food safety management (e.g., pathogen control and toxin mitigation). ABSTRACT This systematic
Chinaza Godswill Awuchi
wiley   +1 more source

The Impact of Immunoglobulins on Cardiovascular Diseases and Lipid Profiles in Elderly and Middle‐Aged Chinese Individuals: A 15‐Year Retrospective Study

Journal of Clinical Laboratory Analysis, EarlyView.
In a 15‐year retrospective study of Chinese adults over 45, we explored the links between immunoglobulins, CVDs, and lipid profiles. Temporal increases in IgG and IgA were positively associated with FFAs, offering new insights into humoral immunity and lipid metabolism, suggesting a mechanistic link between humoral immunity and dyslipidemia ...
Ya Li, Li Jiao, Yuan Gao, Xue‐Feng Ni
wiley   +1 more source

Impact of Dapagliflozin on MRI‐Derived Epicardial Adipose Tissue: Secondary Imaging Analysis of a Randomized Trial

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Epicardial adipose tissue (EAT) is a metabolically active fat depot associated with cardiovascular risk and represents a modifiable imaging biomarker. Studies have shown that sodium–glucose cotransporter‐2 (SGLT2) inhibitors reduce EAT thickness in patients with type 2 diabetes mellitus (T2DM). However, it is unclear whether this is
Min Jae Cha, Negar Firoozeh, Anna V. Naumova, Peter Muzi, Karen G. Ordovas, Dennis D. Wang, Daniel Isquith, Chuck Maynard, Xue‐Qiao Zhao, Francis Kim   +9 more
wiley   +1 more source