Results 151 to 160 of about 29,093 (266)

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Letter to the Editor: Fibroblast activation protein and the CaMKIIδ-Calcineurin-NFAT pathway in diabetic HFpEF. [PDF]

Clin Sci (Lond)
Nie X, Feng X, Xu C.
europepmc   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Challenges in Balancing Hemostasis and Thrombosis in Therapy Tailoring for Hemophilia: A Narrative Review. [PDF]

Int J Mol Sci
Kenet G, Levy-Mendelovich S, Livnat T, Brenner B.   +3 more
europepmc   +1 more source

Inhibition of Protein Fibrillation by Hydrogen Sulfide¹

, 2019
Manuel F. Rosario-Alomar, Tatiana Quiñones-Ruiz, Dmitry Kurouski, Valentin Sereda, Eduardo DeBarros-Ferreira, Lorraine De Jesús-Kim, Samuel Hernández-Rivera, Dmitri V. Zagorevski, Leishla M. Cruz-Collazo, Igor K. Lednev, Juan López-Garriga   +10 more
openaire   +2 more sources

Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications

The Journal of Physiology, EarlyView.
Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach, Laura Bevis, Cynthia Nwanna, Alexander M Zolotarev, Mahmoud Ehnesh, Semhar Biniam Misghina, Sayed Al‐Aidarous, Shohreh Honarbakhsh, Caroline H. Roney   +8 more
wiley   +1 more source

ETV1 orchestrates a self-reinforcing ERK1/2-RSK3 signaling loop to drive atrial fibrillation pathogenesis: implications for targeted therapy. [PDF]

Sci Rep
Wu M, Peng Y, Zheng H, Chen J, Zhang J.
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Preoperative transcutaneous vagus nerve stimulation as a novel strategy to prevent postoperative atrial fibrillation in calcific aortic valve disease: mechanistic insights and translational perspectives. [PDF]

Front Cardiovasc Med
Bergeon J, Chassagne F, Fanget M, Merlet AN, Avril S, Féasson L, Roche F, Bäck M, Hupin D.   +8 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source