Results 191 to 200 of about 4,544,497 (292)

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Macrophage Immunometabolism in Epicardial Adipose Tissue and Obesity-Related Atrial Fibrillation. [PDF]

J Inflamm Res
Xia L, Sun X, Xie L, Liu S, Phanaksri T, Yu Z, Jiang Z, Cao X.   +7 more
europepmc   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation. [PDF]

Front Pharmacol
Niu R, Li J, Fang H, Zhao W, Dong C, Han N, Chen M, Ma L, Li L, Fan Y, Zhu B, Bie B, Wu J, Matsuura H, Horie M.   +14 more
europepmc   +1 more source

Doxorubicin‐induced Cardiotoxicity in Dogs: A Narrative Review

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Doxorubicin, an anthracycline widely used in both human and veterinary oncology, is highly effective against a variety of malignancies in dogs, including lymphomas, sarcomas and carcinomas. Despite its efficacy, doxorubicin exposure can be associated with cardiotoxicity, which may present acutely or chronically, potentially leading to severe ...
Supita Sunpongsri, Tom Roos, Ronette Gerhing, Maurice Zandvliet, Giorgia Santarelli   +4 more
wiley   +1 more source

Impact of Downregulated Inflammation via the IL6R Asp358Ala Variant on Atrial Fibrillation Recurrence Following Ablation. [PDF]

JACC Adv
Kim JA, Kim JJ, Ternes CMP, Chelu MG, Curtis AB.   +4 more
europepmc   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Dickkopf-3 (DKK3) in cardiovascular diseases: from a stress-responsive biomarker to a potential therapeutic target. [PDF]

Front Pharmacol
Fu X, Dai J, Wang X, Qiu L, Hua Y.
europepmc   +1 more source