Results 261 to 270 of about 132,897 (299)

The structure of fibrils from ‘misfolded’ proteins

Current Opinion in Structural Biology, 2015
Recent developments in solid-state NMR have opened the way to the structural analysis of protein fibrils, with the power of studying them at atomic resolution. Solid-state NMR is a relatively new player in the field of structural biology, and reliable approaches to successfully tackle 3D structures have been developed and applied recently.
Meier, Beat H, Böckmann, Anja
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SAS-Based Studies of Protein Fibrillation

2017
Protein fibrillation is associated with a number of fatal amyloid diseases (e.g. Alzheimer's and Parkinson's diseases). From a structural point of view, the aggregation process starts from an ensemble of native states that convert into transiently formed oligomers, higher order assemblies and protofibrils and, finally, fibrils.
Marasini, Carlotta, Vestergaard, Bente
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Characterization of fibrillated antioxidant whey protein hydrolysate and comparison with fibrillated protein solution

Food Hydrocolloids, 2016
Abstract Whey proteins were hydrolyzed to reach maximum in vitro antioxidant activity, followed by fibrillation via heating at pH 2.0. Heating of either whey protein isolate (WPI) or its antioxidant hydrolysate (WPH) formed fibrillar structures with ...
Mehdi Mohammadian, Ashkan Madadlou
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Amyloid fibril formation from crude protein mixtures

Biotechnology Progress, 2011
AbstractAmyloid fibrils have potential as bionanomaterials. A bottleneck in their commercial use is the cost of the highly purified protein typically needed as a starting material. Thus, an understanding of the role of heterogeneity in the mixtures from which amyloid fibrils are formed may inform production of these structures from readily available ...
Shiva P, Rao, Susie J, Meade, Nigel I, Joyce, Jackie P, Healy, Kevin H, Sutton, Nigel G, Larsen, Juliet A, Gerrard   +6 more
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C-Reactive Protein in Lone Atrial Fibrillation

The American Journal of Cardiology, 2006
An inflammatory cause of atrial fibrillation (AF) has been proposed on the basis of the presence of lymphocytic infiltrates in the biopsy results of patients with lone AF, alterations of C-reactive protein (CRP) and interleukin-6 levels in subjects with AF, and the time course of postoperative AF. Many previous studies exploring inflammatory factors in
Patrick T, Ellinor, Adrian, Low, Kristen K, Patton, Marisa A, Shea, Calum A, MacRae   +4 more
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Modulation of Tau Protein Fibrillization by Oleocanthal

Journal of Natural Products, 2012
Among the phenolic compounds extracted from extra virgin olive oil, oleocanthal (1) has attracted considerable attention in the modulation of many human diseases, such as inflammation and Alzheimer's disease (AD). Indeed, 1 is capable of altering the fibrillization of tau protein, which is one of the key factors at the basis of neurodegenerative ...
MONTI, Maria Chiara, MARGARUCCI, LUIGI, RICCIO, Raffaele, CASAPULLO, Agostino   +3 more
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Endocrine Amyloid Fibril Proteins

1986
Since long deposition of amyloid has been known to occur more or less frequently in polypeptide hormone producing tissues and tumours originating from such tissues. Well known examples are the islets of Langerhans and medullary carcinoma of the thyroid gland. Peptide hormone expressing tissues that often contain amyloid deposits are listed in Table I.
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Amyloid fibril protein in familial amyloid polyneuropathy

Neurology, 1981
Amyloid fibril protein was purified from organs of patients with familial amyloid polyneuropathy (Nagano prefecture, Japan). When compared with amyloid fibril protein from primary amyloidosis and secondary amyloidosis, the protein from familial amyloid polyneuropathy was shown to differ in the molecular weight of the subunit.
S, Shoji, A, Okano
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Kinetics of protein fibrillation controlled by fibril elongation.

Proteins, 2015
Numerous proteins have the ability to assemble into fibrillar aggregates which are of great interest, because they feature in scores of human diseases and many technological products. In the present work, we analyze the kinetics of protein fibrillation when the process is governed solely by elongation of initially appeared fibrils in the protein ...
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The biochemical genetics of amyloid fibril proteins

La Ricerca in Clinica e in Laboratorio, 1989
Amyloidoses are a very heterogeneous set of diseases, characterized by extracellular deposition of fibrillar proteins in different tissues. It is still a matter of debate whether the different forms of amyloidosis can share some common etiological mechanisms, or they are completely unrelated. The biochemical characterization of the protein component of
A O, Carbonara, A, Bottaro
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