Results 11 to 20 of about 6,771,465 (361)

Protein folds and protein folding [PDF]

Protein Engineering Design and Selection, 2010
The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds).
R Dustin, Schaeffer, Valerie, Daggett
openaire   +2 more sources

Harnessing protein folding neural networks for peptide–protein docking

Nature Communications, 2021
Highly accurate protein structure predictions by deep neural networks such as AlphaFold2 and RoseTTAFold have tremendous impact on structural biology and beyond.
Tomer Tsaban, Julia K. Varga, O. Avraham, Ziv Ben-Aharon, A. Khramushin, Ora Schueler‐Furman   +5 more
semanticscholar   +1 more source

Protein structure generation via folding diffusion [PDF]

Nature Communications, 2022
The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases.
Kevin E. Wu, Kevin Kaichuang Yang, Rianne van den Berg, James Zou, Alex X. Lu, Ava P. Amini   +5 more
semanticscholar   +1 more source

Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection

Cells, 2023
Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang, Chiye Kim, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source

The measurement of true initial rates is not always absolutely necessary to estimate enzyme kinetic parameters

Scientific Reports, 2023
In the chapters dealing with enzyme reactions, the authors of all Biochemistry textbooks and of even more specialized texts consider that the characteristic parameters (k cat and K m ) must be determined under initial or steady-state rate conditions ...
Jean-Marie Frère, Olivier Verlaine, André Matagne   +2 more
doaj   +1 more source

Susceptibility of Beavers to Chronic Wasting Disease

Biology, 2022
Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst, Serene Wohlgemuth, Jing Yang, Andrew R. Castle, Diana Martinez Moreno, Alicia Otero, Judd M. Aiken, David Westaway, Debbie McKenzie   +8 more
doaj   +1 more source

Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Journal of Nanobiotechnology, 2022
Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of Alzheimer’s disease (AD) pathology ...
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar   +7 more
doaj   +1 more source

Folding of Proteins with Diverse Folds [PDF]

Biophysical Journal, 2006
Using parallel tempering simulations with high statistics, we investigate the folding and thermodynamic properties of three small proteins with distinct native folds: the all-helical 1RIJ, the all-sheet beta3s, and BBA5, which has a mixed helix-sheet fold.
Mohanty, S., Hansmann, U. H. E.
openaire   +3 more sources

Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects

Biomolecules, 2020
The accumulation of tau protein in the form of filamentous aggregates is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE).
Hadeel Alyenbaawi, W. Ted Allison, Sue-Ann Mok   +2 more
doaj   +1 more source

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bioactive Materials, 2021
Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar   +6 more
doaj   +1 more source