Results 11 to 20 of about 6,813,928 (408)
Chirality and Protein Folding [PDF]
Journal of Physics: Condensed Matter, 2004 There are several simple criteria of folding to a native state in model proteins. One of them involves crossing of a threshold value of the RMSD distance away from the native state. Another checks whether all native contacts are established, i.e. whether
Bernstein F C +7 more
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Comprehensive Folding Variations for Protein Folding [PDF]
Proteins: Structure, Function, and Bioinformatics, 2022 The revelation of protein folding is a challenging subject in both discovery and description. Except acquirement of accurate 3D structure for protein stable state, another big hurdle is how to discover structural flexibility for protein innate character.
Jiaan Yang +10 more
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Harnessing protein folding neural networks for peptide–protein docking
Nature Communications, 2021 Highly accurate protein structure predictions by deep neural networks such as AlphaFold2 and RoseTTAFold have tremendous impact on structural biology and beyond.
Tomer Tsaban +5 more
semanticscholar +1 more source
BMC Biology, 2021 Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang +8 more
doaj +1 more source
Protein folds and protein folding [PDF]
Protein Engineering Design and Selection, 2010 The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds).
Valerie Daggett, R. Dustin Schaeffer
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Folding of Proteins with Diverse Folds [PDF]
Biophysical Journal, 2006 Using parallel tempering simulations with high statistics, we investigate the folding and thermodynamic properties of three small proteins with distinct native folds: the all-helical 1RIJ, the all-sheet beta3s, and BBA5, which has a mixed helix-sheet fold.
Ulrich H. E. Hansmann +2 more
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Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection
Cells, 2023 Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang +3 more
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Scientific Reports, 2023 In the chapters dealing with enzyme reactions, the authors of all Biochemistry textbooks and of even more specialized texts consider that the characteristic parameters (k cat and K m ) must be determined under initial or steady-state rate conditions ...
Jean-Marie Frère +2 more
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Susceptibility of Beavers to Chronic Wasting Disease
Biology, 2022 Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst +8 more
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Single-Molecule Studies of Protein Folding with Optical Tweezers.
Annual Review of Biochemistry, 2020 Manipulation of individual molecules with optical tweezers provides a powerful means of interrogating the structure and folding of proteins. Mechanical force is not only a relevant quantity in cellular protein folding and function, but also a convenient ...
C. Bustamante +3 more
semanticscholar +1 more source