Results 201 to 210 of about 6,771,465 (361)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A multichaperone condensate enhances protein folding in the endoplasmic reticulum. [PDF]

Nat Cell Biol
Leder A, Mas G, Szentgyörgyi V, Jakob RP, Maier T, Spang A, Hiller S.   +6 more
europepmc   +1 more source

Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles [PDF]

, 2018
Péter Schmidt, Brian J. Bender, Anette Kaiser, Khushboo Gulati, Holger A. Scheidt, Heidi E. Hamm, Jens Meiler, Annette G. Beck‐Sickinger, Daniel Huster   +8 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations. [PDF]

Signal Transduct Target Ther
Kuzu OF, Granerud LJT, Saatcioglu F.
europepmc   +1 more source

Recognition of analogous and homologous protein folds--assessment of prediction success and associated alignment accuracy using empirical substitution matrices [PDF]

, 1998
Robert B. Russell, Mansoor Saqi, Paul A. Bates, Roger A. Sayle, Michael J.E. Sternberg   +4 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

How the Extent of Protein Folding and Oligomerization Modulate Condensate Formation and Properties. [PDF]

J Phys Chem Lett
Edelstein I, Levy Y.
europepmc   +1 more source

Prediction of Protein Folding Pathways under Entropy-Loss Constraints using Quadratic Programming-Based Nonlinear Control

, 2023
Alireza Mohammadi, Mark W. Spong
openalex   +1 more source