Results 21 to 30 of about 6,771,465 (361)
Scientific Reports, 2021 In light of legislative changes and the widespread use of cannabis as a recreational and medicinal drug, delayed effects of cannabis upon brief exposure during embryonic development are of high interest as early pregnancies often go undetected.
Richard Kanyo +6 more
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Biomolecules, 2021 The complex topologies of large multi-domain globular proteins make the study of their folding and assembly particularly demanding. It is often characterized by complex kinetics and undesired side reactions, such as aggregation. The structural simplicity
Jessica Guillerm +3 more
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Molecular Neurodegeneration, 2017 Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes.
Ghazaleh Eskandari-Sedighi +11 more
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Resource-efficient quantum algorithm for protein folding [PDF]
npj Quantum Information, 2019 Predicting the three-dimensional structure of a protein from its primary sequence of amino acids is known as the protein folding problem. Due to the central role of proteins’ structures in chemistry, biology and medicine applications, this subject has ...
A. Robert +3 more
semanticscholar +1 more source
The Standard Scrapie Cell Assay: Development, Utility and Prospects
Viruses, 2015 Prion diseases are a family of fatal neurodegenerative diseases that involve the misfolding of a host protein, PrPC. Measuring prion infectivity is necessary for determining efficacy of a treatment or infectivity of a prion purification procedure; animal
Jacques van der Merwe +3 more
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A code within the genetic code: codon usage regulates co-translational protein folding
Cell Communication and Signaling, 2020 The genetic code is degenerate, and most amino acids are encoded by two to six synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a universal feature of all genomes examined.
Yi Liu
semanticscholar +1 more source
Distance-based protein folding powered by deep learning [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Accurate description of protein structure and function is a fundamental step toward understanding biological life and highly relevant in the development of therapeutics. Although greatly improved, experimental protein structure determination
Jinbo Xu
semanticscholar +1 more source
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
eLife, 2021 Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to
Hadeel Alyenbaawi +8 more
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Single-Molecule Studies of Protein Folding with Optical Tweezers.
Annual Review of Biochemistry, 2020 Manipulation of individual molecules with optical tweezers provides a powerful means of interrogating the structure and folding of proteins. Mechanical force is not only a relevant quantity in cellular protein folding and function, but also a convenient ...
C. Bustamante +3 more
semanticscholar +1 more source
Journal of Nanobiotechnology, 2023 Evidence suggests that increased level/aggregation of β-amyloid (Aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of Alzheimer’s disease (AD), the leading cause of dementia in the ...
Karthivashan Govindarajan +1 more
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