Results 191 to 200 of about 932,427 (312)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Accuracy of estimating total-tract fibre and protein fractions digestibilities using uNDF, uNDFom, and AIA markers, and their NIRS prediction potential in dairy sheep and goats. [PDF]

PLoS One
Danese T, Guerra A, Simoni M, Mantovani G, Goi A, Pitino R, Mavrommatis A, De Marchi M, Righi F, Tsiplakou E.   +9 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Measurement of bovine (<i>Bos taurus</i>) serum albumin by different methods and the comparison of protein fractions determined by capillary zone electrophoresis and agarose gel electrophoresis. [PDF]

PeerJ
da Fonseca LA, Montiani-Ferreira F, Rodriguez M, Bittar JHJ, Girardi FM, Moraes TMA, Cray C.   +6 more
europepmc   +1 more source

Effects of Replacing Ensiled-Alfalfa with Fresh-Alfalfa on Dynamic Fermentation Characteristics, Chemical Compositions, and Protein Fractions in Fermented Total Mixed Ration with Different Additives. [PDF]

Animals (Basel), 2021
Gao R, Luo Y, Xu S, Wang M, Sun Z, Wang L, Yu Z.   +6 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effect of ultrasound pre-treatments before enzymatic hydrolysis on physicochemical, nutritional and functional properties of insoluble protein fractions obtained from Atlantic mackerel side streams. [PDF]

Bioresour Bioprocess
Cropotova J, Kvangarsnes K, Kotsoni E, Mozuraityte R, Standal IB, Le Gall A, Rustad T.   +6 more
europepmc   +1 more source

Effect of Seminal Plasma Protein Fractions on Stallion Sperm Cryopreservation. [PDF]

Int J Mol Sci, 2020
Bubenickova F, Postlerova P, Simonik O, Sirohi J, Sichtar J.   +4 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Temporal profile of amino acids and protein fractions in the developing kernel of maize germplasm. [PDF]

Sci Rep
Devi V, Sethi M, Kaur C, Singh V, Kumar R, Chaudhary DP.   +5 more
europepmc   +1 more source