Results 71 to 80 of about 11,494,730 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Indoor bacterial, fungal and viral species and functional genes in urban and rural schools in Shanxi Province, China–association with asthma, rhinitis and rhinoconjunctivitis in high school students

Microbiome, 2021
Background Studies in developed countries have reported that the prevalence of asthma and rhinitis is higher in urban areas than in rural areas, and this phenomenon is associated with urbanization and changing indoor microbiome exposure.
Xi Fu, Zheyuan Ou, Mei Zhang, Yi Meng, Yanling Li, Jikai Wen, Qiansheng Hu, Xin Zhang, Dan Norbäck, Yiqun Deng, Zhuohui Zhao, Yu Sun   +11 more
doaj   +1 more source

STRUCTURE AND FUNCTION OF G PROTEINS

Pharmacology & Therapeutics, 1991
G proteins are heterotrimeric proteins involved in the transduction of a variety of external signals in all eukaryotic organisms. This review analyzes the molecular aspects of G protein structure and function. The cloning of cDNAs coding for a great variety of G protein subunits has allowed us to deduce the primary and secondary structure of the ...
Olate, Juan, Allende, Jorge E.
openaire   +3 more sources

An experimental comparison of classification algorithms for hierarchical prediction of protein function [PDF]

, 2007
Some data can be naturally organised as a hierarchy of classes. The classification of data in such a hierarchy poses some unique challenges to data miners. One particular case of this is the classification of GPCR proteins by their function.
Matthew N. Davies, Timmis, Jon, Miguel Mendao, Flower, Darren R., Secker, Andrew D., Jon Timmis, Mendao, Miguel, Alex A. Freitas, Davies, Matthew N., Andrew Secker, Freitas, Alex A., Darren R. Flower   +11 more
core  

Predicting protein function by machine learning on amino acid sequences – a critical evaluation [PDF]

, 2007
Copyright @ 2007 Al-Shahib et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use ...
Gilbert, DR, Al-Shahib, A, Breitling, Rainer, Gilbert, D, Breitling, R., Ali Al-Shahib, Breitling, Rainer,, Al-Shahib, Ali, Rainer Breitling, Gilbert, David R., Breitling, R, Breitling Rainer, Shahib, Ali Al-,, Gilbert, D.R., Al-Shahib Ali, Gilbert, David R.,, David R Gilbert, Gilbert David R, Al-Shahib, A., Narváez Prado, Carlos Wilfredo   +19 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC

Cell Death and Disease, 2023
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with high morbidity and mortality worldwide. Although the dysregulation of BARX1 expression has been shown to be associated with malignant cancers, including NSCLC, the underlying
Tongjia Zhang, Lizhen Qiu, Jiashun Cao, Qiu Li, Lifan Zhang, Guoshun An, Juhua Ni, Hongti Jia, Shuyan Li, Kailong Li   +9 more
doaj   +1 more source

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Involvement of the Metallothionein gene OsMT2b in Drought and Cadmium Ions Stress in Rice

Rice
Abiotic stress is one of the major factors restricting the production of rice (Oryza sativa L.). Developing rice varieties with dual abiotic stress tolerance is essential to ensure sustained rice production, which is necessary to illustrate the ...
Yanxin Chen, Ying He, Yibin Pan, Yunyi Wen, Lili Zhu, Jieer Gao, Weiting Chen, Dagang Jiang   +7 more
doaj   +1 more source