Results 81 to 90 of about 521,366 (318)
EMBO Molecular Medicine, 2016 Bone anabolic agents promoting bone formation and rebuilding damaged bones would ideally overcome the limitations of anti‐resorptive therapy, the current standard prescription for osteoporosis.
Hyun‐Yi Kim +10 more
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CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
Life Science Alliance, 2019 Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation. Longitudinal bone growth ceases with growth plate senescence during puberty. However, the molecular mechanisms of this
Sehee Choi +10 more
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STRUCTURE AND FUNCTION OF G PROTEINS
Pharmacology & Therapeutics, 1991 G proteins are heterotrimeric proteins involved in the transduction of a variety of external signals in all eukaryotic organisms. This review analyzes the molecular aspects of G protein structure and function. The cloning of cDNAs coding for a great variety of G protein subunits has allowed us to deduce the primary and secondary structure of the ...
Olate, Juan, Allende, Jorge E.
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Structure and function of proteins
Bioscience Reports, 1988 It is now many years since Linderstr6m-Lang suggested that the threedimensional conformation of a protein is the end result of its primary, secondary and tertiary structures. The protein's primary structure is represented by its amino acid sequence and the secondary structure by its tr-helices and E-sheets; its final three-dimensional conformation is ...
openaire +2 more sources
Functional classification of proteins and protein variants [PDF]
Proceedings of the National Academy of Sciences, 2004 To help characterize the diversity in biological function of proteins emerging from the analysis of whole genomes, we present an operational definition of biological function that provides an explicit link between the functional classification of proteins and the effects of genetic variation or mutation on protein function.
Albert Y, Lau, Daniel I, Chasman
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Molecular Plant-Microbe Interactions, 2016 In Sinorhizobium meliloti, the nodG gene is located in the nodFEG operon of the symbiotic plasmid. Although strong sequence similarity (53% amino acid identities) between S.
Ya-Hui Mao +4 more
doaj +1 more source