Results 101 to 110 of about 521,366 (318)

Analysis of leukocyte membrane protein interactions using protein microarrays

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Foster-Cuevas, M, Letarte, Michelle, Deborah Hatherley, Foster-Cuevas, Mildred, Hatherley, D, Barclay, AN, Michelle Letarte, Saunders, Nigel, A Neil Barclay, Saunders, NJ, Hatherley, Deborah, Letarte, M, Barclay, Neil, Mildred Foster-Cuevas, Nigel J Saunders, Saunders, Nigel J, Voulgaraki, D, Despina Voulgaraki, Voulgaraki, Despina   +18 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Stochastic machines as a colocalization mechanism for scaffold protein function

, 2013
The axis inhibition (Axin) scaffold protein colocalizes β-catenin, casein kinase Iα, and glycogen synthetase kinase 3β by their binding to Axin’s long intrinsically disordered region, thereby yielding structured domains with flexible linkers.
Uversky, V.N., Rudiger, S.G.D., Maurice, Madelon M., Kurgan, Lukasz, Xue, B., Noutsou, Maria, Romero, P.R., Mizianty, M.J., Dunker, A.K., Cellular Protein Chemistry, Rüdiger, Stefan G. D., Uversky, Vladimir N., Sub Cellular Protein Chemistry, William, Albert M., Romero, Pedro R., Dunker, A. Keith, William, A.M. Jr., Maurice, M.M., Kurgan, L., Rüdiger, Stefan G.D., Xue, Bin, Mizianty, Marcin J., Noutsou, M., William, Albert M., Jr.   +23 more
core   +1 more source

Review for "Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2"

, 2021

openalex   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Human protein function prediction: application of machine learning for integration of heterogeneous data sources

, 2010
Experimental characterisation of protein cellular function can be prohibitively expensive and take years to complete. To address this problem, this thesis focuses on the development of computational approaches to predict function from sequence.
Lobley, A.E.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses

, 2004
Zöllner FG. Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses. Bielefeld (Germany): Bielefeld University; 2004.Für das Verständnis von biologischen Funktionen können Proteindockingverfahren ...
Frank G. Zöllner, Zöllner, Frank Gerrit   +1 more
core  

Exploring the function and evolution of proteins using domain families [PDF]

, 2009
Proteins are frequently composed of multiple domains which fold independently. These are often evolutionarily distinct units which can be adapted and reused in other proteins.
Reid, A.J., Reid, A J
core  

Memory function for protein diffusion

The Journal of Chemical Physics
Standard algorithms to calculate the diffusion constant from computer simulations are based on either the mean-squared displacement or the velocity autocorrelation function of the tagged particle. They register displacements/velocities caused by random forces, but do not address their physical nature.
Setare Sarhangi, Dmitry Matyushov
openaire   +2 more sources