Results 121 to 130 of about 10,675,471 (331)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

mSphere, 2018
The small Tim proteins belong to a group of mitochondrial intermembrane space chaperones that aid in the import of mitochondrial inner membrane proteins with internal targeting signals.
Joseph T. Smith, Ujjal K. Singha, Smita Misra, Minu Chaudhuri   +3 more
doaj   +1 more source

New insights into the mechanism of chloroplast protein import and its integration with protein quality control, organelle biogenesis and development

Journal of Molecular Biology, 2014
The translocons at the outer (TOC) and inner (TIC) envelope membranes of chloroplasts mediate the targeting and import of several thousand nuclear encoded preproteins that are required for organelle biogenesis and homeostasis.
Y. Paila, Lynn G. L. Richardson, D. Schnell   +2 more
semanticscholar   +1 more source

Protein Degradation: An Important Consideration

Poultry Science, 1984
The growth rates of chicks can be varied by dietary manipulations. The rates of synthesis of protein in selected muscles can be measured by using radioactive amino acids. Measurements are made of expired air, plasma, and muscle tissues. Synthesis rates are most rapid in the young chick and turkey. As the bird ages, synthesis rates and degradation rates
M L, Sunde, R W, Swick, C W, Kang
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Translocation arrest by reversible folding of a precursor protein imported into mitochondria [PDF]

, 1989
Passage of precursor proteins through translocation contact sites of mitochondria was investigated by studying the import of a fusion protein consisting of the NH2-terminal 167 amino acids of yeast cytochrome b2 precursor and the complete mouse ...
Herzog, Volker, Hartl, Franz-Ulrich, Rassow, Joachim, Neupert, Walter, Guiard, Bernard, Wienhues, Ulla   +5 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio
In green lineages, chloroplast protein import is mediated by conserved TOC and TIC translocons at the outer and inner envelope membranes, respectively.
Mengyi Li, Xueyang Zhao, Masato Nakai
doaj   +1 more source

Exploitation of an iron transporter for bacterial protein antibiotic import

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The outer membrane (OM) excludes antibiotics such as vancomycin that kill gram-positive bacteria, and so is a major contributor to multidrug resistance in gram-negative bacteria. Yet, the OM is readily bypassed by protein bacteriocins, which
P. White, A. Joshi, P. Rassam, N. G. Housden, Renata Kaminska, Jonathan D Goult, C. Redfield, Laura C. McCaughey, D. Walker, S. Mohammed, C. Kleanthous   +10 more
semanticscholar   +1 more source

Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam

Advanced Engineering Materials, EarlyView.
Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva, Joseph Lavoie, Afsaneh Rabiei   +2 more
wiley   +1 more source

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.

PLoS Biology, 2018
Iron is essential for life. Accessing iron from the environment can be a limiting factor that determines success in a given environmental niche. For bacteria, access of chelated iron from the environment is often mediated by TonB-dependent transporters ...
Rhys Grinter, Iain D Hay, Jiangning Song, Jiawei Wang, Don Teng, Vijay Dhanesakaran, Jonathan J Wilksch, Mark R Davies, Dene Littler, Simone A Beckham, Ian R Henderson, Richard A Strugnell, Gordon Dougan, Trevor Lithgow   +13 more
doaj   +1 more source