Results 101 to 110 of about 1,237,822 (372)
Interactive proteomics: what lies ahead?
BioTechniques, 2008 Interactive proteomics addresses the physical associations among proteins and establishes global, disease-, and pathway-specific protein interaction networks.
Bernhard Suter +2 more
doaj +1 more source
Protein-protein interactions: network analysis and applications in drug discovery [PDF]
, 2012 Physical interactions among proteins constitute the backbone of cellular function, making them an attractive source of therapeutic targets. Although the challenges associated with targeting protein-protein interactions (PPIs) -in particular with small ...
Bultinck, Jennyfer +2 more
core +2 more sources
Nucleic Acids Research, 2005 Since its initial description, the yeast two-hybrid (Y2H) system has been widely used for the detection and analysis of protein–protein interactions.
P. Clarke, P. Ó. Cuív, M. O'Connell
semanticscholar +1 more source
Mapping of protein- and chromatin-interactions at the nuclear lamina [PDF]
Nucleus, 2010 The nuclear envelope and the lamina define the nuclear periphery and are implicated in many nuclear processes including chromatin organization, transcription and DNA replication. Mutations in lamin A proteins, major components of the lamina, interfere with these functions and cause a set of phenotypically diverse diseases referred to as laminopathies ...
Tom Misteli +2 more
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. [PDF]
, 2017 DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Chen, Xuemei +20 more
core +3 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Molecular Systems Biology, 2009 Large‐scale proteomic approaches have been used to study signaling pathways. However, identification of biologically relevant hits from a single screen remains challenging due to limitations inherent in each individual approach.
Bryan W Miller +9 more
doaj +1 more source
PCSF: An R-package for network-based interpretation of high-throughput data. [PDF]
PLoS Computational Biology, 2017 With the recent technological developments a vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases. The current bioinformatics challenge is to interpret the data and underlying biology, where efficient ...
Murodzhon Akhmedov +6 more
doaj +1 more source
Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. [PDF]
, 2018 Previous genetic and biochemical studies from Saccharomyces cerevisiae have identified a critical ribosome-associated quality control complex (RQC) that facilitates resolution of stalled ribosomal complexes.
Bennett, Eric J +5 more
core +2 more sources