Results 111 to 120 of about 271,486 (262)

Predicting the Impact of Alternative Splicing on Plant MADS Domain Protein Function

, 2012
Several genome-wide studies demonstrated that alternative splicing (AS) significantly increases the transcriptome complexity in plants. However, the impact of AS on the functional diversity of proteins is difficult to assess using genome-wide approaches.
Morabito, G., Dijk, A.D.J., van, Severing, E.I., Busscher-Lange, J., Ham, R.C.H.J., van, Immink, G.H.   +5 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Integrative RNA-seq analysis reveals immune-related hub genes NR4A1 and FOSB in recurrent spontaneous abortion: A bioinformatics study

International Journal of Reproductive BioMedicine
Background: Recurrent spontaneous abortion (RSA) impacts 1–5% of women of reproductive age, constituting a significant health issue. Despite advances in our understanding of RSA, the fundamental molecular mechanisms remain inadequately defined ...
Kosar Babaei, Saman Morovat, Hossein Mozdarani, Misa Naghdipour Mirsadeghi, Seyed Reza Mirhafez, Ebrahim Mirzajani, Mohsen Aziminezhad, Ali Akbar Samadani   +7 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

PutidaNET: Interactome database service and network analysis of Pseudomonas putida KT2440

BMC Genomics, 2009
Background Pseudomonas putida KT2440 (P. putida KT2440) is a highly versatile saprophytic soil bacterium. It is a certified bio-safety host for transferring foreign genes. Therefore, the bacterium is used as a model organism for genetic and physiological
Park Daeui, Ryu Jea-Woon, Jho Seong-Woong, Kim Byoung-Chul, Choi Jong-Soon, Park Seong-Jin, Lee Kyung-A, Bhak Jong, Kim Seung Il   +8 more
doaj   +1 more source

The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]

, 1991
The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Bühler, Bernhard, Münch, Konrad, Koszinowski, Ulrich H., Messerle, Martin   +3 more
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

The Cyst Nematode SPRYSEC Protein RBP-1 Elicits Gpa2- and RanGAP2-Dependent Plant Cell Death

, 2009
Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr) proteins that are delivered to the host cytoplasm.
Moffett, Peter, Alexandra Blanchard, Goverse Aska, Smant, G., Sacco, Melanie Ann, Koropacka, Kamila, Smant Geert, Peter Moffett, Grenier, E., Jaubert, Marianne J., Grenier, Eric, Goverse, A., Blanchard, A., Kamila Koropacka, Melanie Ann Sacco, Aska Goverse, Goverse, Aska, Moffett, P., Smant, Geert, Geert Smant, Koropacka, K.B., Blanchard, Alexandra, Moffett Peter, Jaubert Marianne J., Koropacka Kamila, Eric Grenier, Sacco, M.A., Sacco Melanie Ann, Marianne J Jaubert, Jaubert, M.J., Grenier Eric, Blanchard Alexandra   +31 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source