Results 201 to 210 of about 543,220 (340)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Protein interaction mapping: ADrosophilacase study [PDF]

, 2005
Étienne Formstecher, Sandra Aresta, Vincent Collura, Alexandre Hamburger, Alain Meil, Alexandra Trehin, Céline Reverdy, Virginie M.S. Betin, Sophie Maire, Christine Brun, Bernard Jacq, Monique Arpin, Yohanns Bellaı̈che, Savério Bellusci, Philippe Benaroch, Michel Bornens, R. Chanet, Philippe Chavrier, Olivier Delattre, Valérie Doye, Richard G. Fehon, Gérard Faye, Thierry Galli, Jean‐Antoine Girault, Bruno Goud, Jean de Gunzburg, Ludger Johannes, Marie-Pierre Junier, Vincent Mirouse, Ashim Mukherjee, D. Papadopoulo, Franck Perez, Anne Plessis, Carine Rossé, Simon Saule, Dominique Stoppa‐Lyonnet, Alain Vincent, Michael White, Pierre Legrain, Jérôme Wojcik, Jacques Camonis, Laurent Daviet   +41 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

DMS‐seq for In Vivo Genome‐Wide Mapping of Protein‐DNA Interactions and Nucleosome Centers [PDF]

, 2018
Taichi Umeyama, Takashi Ito
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Mapping the MinE Site Involved in Interaction with the MinD Division Site Selection Protein of Escherichia coli

, 2003
Z. Luyan, Glenn F. King, Lawrence Rothfield   +2 more
openalex   +1 more source

Mapping of Chikungunya Virus Interactions with Host Proteins Identified nsP2 as a Highly Connected Viral Component [PDF]

, 2012
Mehdi Bouraï, Marianne Lucas‐Hourani, Hans Henrik Gad, Christian Drosten, Yves Jacob, Lionel Tafforeau, Patricia Cassonnet, Louis Jones, Delphine Judith, Thérèse Couderc, Marc Lecuit, Patrice André, Beate M. Kümmerer, Vincent Lotteau, Philippe Desprès, Frédéric Tangy, Pierre‐Olivier Vidalain   +16 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source