Results 191 to 200 of about 292,859 (260)

Conditional Proximity Labeling in Complex Biological Systems: Design Principles, Emerging Platforms, and Applications. [PDF]

Int J Mol Sci
Yang JM, Zhu MD, Liu SL, Yang L, Wang ZG.   +4 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Integrated analyses identify MAN1B1 as a candidate regulator of chemotherapeutic tolerance and immunosuppression in bladder cancer. [PDF]

Front Immunol
Jiang M, Zhao D, Zhang L, Zhu D, Li J, Zheng Z.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Spatial multi-omics and AI for decoding tumor heterogeneity: implications for target discovery and therapy resistance. [PDF]

Neoplasia
Raheem K, Yakasiri SS, Guda C.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Computational Prediction of the Therapeutic Mechanisms From the Turmeric-Pueraria-Coix Seed Botanical Formula in Rheumatoid Arthritis. [PDF]

Food Sci Nutr
Lan W, Lu Q, Rui X, Li K, Su C, Su Q, Huang Y, Shi R, Chen W, Tang F.   +9 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Transcriptional and Functional Insights Into the All-Stage Resistance Gene GmRmd1-Mediated Regulation of Resistance to Powdery Mildew in Soybean. [PDF]

Mol Plant Pathol
Liu G, Ling C, Xu T, Zhang X, Jiang J, Xu X, Li L, Zhang J, Hu B, Liu M, He Y, Yang C.   +11 more
europepmc   +1 more source