Results 261 to 270 of about 543,220 (340)

The role of cytosine modification symmetry in mammalian epigenome regulation. [PDF]

Chem Sci
Cakil ZV, Engelhard L, Summerer D.
europepmc   +1 more source

Multi-Omic Transcription Regulatory Network Mapping Identifies Targetable Oncogenic TF-Cofactor Relationship between IRF4 and p300 in Multiple Myeloma, and Is Used to Improve TF Protein-Protein Interaction Methodology [PDF]

Yupeng Zheng, Walter F. Lenoir, Marek J. Kobylarz, Jun Li, Tamara D. Hopkins, Michael R. McKeown, Michelle G. Shum, Kunio Mori, Elizabeth C Townsend, B. Wesley Trotter, Peter B. Rahl, Nikolaus D. Obholzer, Charles Y. Lin   +12 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine. [PDF]

Psychopharmacology (Berl)
Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, de Villena FP, Valdar W, Bubier JA, Tarantino LM.   +9 more
europepmc   +1 more source

Author response: Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamic interactions

Rupinder Singh Jandu, A. K. Bhattacharya, Frank Antony, Mohammed Al‐Seragi, H Aoki, Mohan Babu, Franck Duong   +6 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Cytoscape files - Mapping Protein–Protein Interaction Dysfunction Across the Alzheimer's Spectrum Reveals Early, Mislocalization-Driven Network Failure

Chakrabarty, Souparna
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Fine mapping and cloning of an intersubspecific reproductive isolation locus <i>MSHB1</i> in rice. [PDF]

Mol Breed
Wang X, Zhang Z, Zhao J, Chen M, Gong J, Han Y, Wei X, Huang X, Fan J.   +8 more
europepmc   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Phillips, Michael, Holla, Andrea, Wojtas, Magdalena, Chowdhury, Aritra, Sottini, Andrea, König, Sebastian L B, Mutter, Natalie, Lamb, Nick, Huihui, Jonathan, Lopko, Monika, Soranno, Andrea, Nettels, Daniel, Ożyhar, Andrzej, Schuler, Benjamin, Ghosh, Kingshuk   +14 more
openalex   +1 more source