Results 71 to 80 of about 1,237,822 (372)

Pooled‐matrix protein interaction screens using Barcode Fusion Genetics

Molecular Systems Biology, 2016
High‐throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major ...
Nozomu Yachie, Evangelia Petsalaki, Joseph C Mellor, Jochen Weile, Yves Jacob, Marta Verby, Sedide B Ozturk, Siyang Li, Atina G Cote, Roberto Mosca, Jennifer J Knapp, Minjeong Ko, Analyn Yu, Marinella Gebbia, Nidhi Sahni, Song Yi, Tanya Tyagi, Dayag Sheykhkarimli, Jonathan F Roth, Cassandra Wong, Louai Musa, Jamie Snider, Yi‐Chun Liu, Haiyuan Yu, Pascal Braun, Igor Stagljar, Tong Hao, Michael A Calderwood, Laurence Pelletier, Patrick Aloy, David E Hill, Marc Vidal, Frederick P Roth   +32 more
doaj   +1 more source

Structure-function mapping of a heptameric module in the nuclear pore complex. [PDF]

, 2012
The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast ...
Chait, Brian T, Diaz-Avalos, Ruben, Fernandez-Martinez, Javier, Franke, Josef D, Phillips, Jeremy, Rout, Michael P, Sali, Andrej, Sekedat, Matthew D, Stokes, David L, Velazquez-Muriel, Javier, Williams, Rosemary   +10 more
core   +2 more sources

Comparative mapping of host–pathogen protein–protein interactions [PDF]

Current Opinion in Microbiology, 2015
Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications.
Manon Eckhardt, Jason A. Wojcechowskyj, Nevan J. Krogan, Nevan J. Krogan, Priya S. Shah   +4 more
openaire   +5 more sources

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Structural and Evolutionary Insights Into the Binding of Host Receptors by the Rabies Virus Glycoprotein

Frontiers in Cellular and Infection Microbiology, 2021
Rabies represents a typical model for spillover of zoonotic viral diseases among multiple hosts. Understanding the success of rabies virus (RV) in switching hosts requires the analysis of viral evolution and host interactions.
Manar E. Khalifa, Manar E. Khalifa, Leonie Unterholzner, Muhammad Munir   +3 more
doaj   +1 more source

ProDGe: investigating protein-protein interactions at the domain level [PDF]

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Adrian Schrö, Andreas Drä, Andreas Zell, Clemens Wrzodek, Finja Bü, Florian Mittag   +5 more
core   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Proteome-wide prediction and analysis of the Cryptosporidium parvum protein–protein interaction network through integrative methods

Computational and Structural Biotechnology Journal, 2022
As one of the most studied Apicomplexan parasite Cryptosporidium, Cryptosporidium parvum (C. parvum) causes worldwide serious diarrhea disease cryptosporidiosis, which can be deadly to immunodeficiency individuals, newly born children, and animals ...
Panyu Ren, Xiaodi Yang, Tianpeng Wang, Yunpeng Hou, Ziding Zhang   +4 more
doaj  

Quantitative trait loci conferring grain mineral nutrient concentrations in durum wheat 3 wild emmer wheat RIL population [PDF]

, 2009
Mineral nutrient malnutrition, and particularly deficiency in zinc and iron, afflicts over 3 billion people worldwide. Wild emmer wheat, Triticum turgidum ssp. dicoccoides, genepool harbors a rich allelic repertoire for mineral nutrients in the grain.
A Blanco, A Blanco, A Börner, A Distelfeld, A Distelfeld, A Mesfin, A Morgounov, A Yilmaz, Abraham B. Korol, AH Paterson, AJ Barneix, Atilla Yazici, B Feil, BM Waters, C Groos, C Hotz, C Löffler, C Uauy, CN Law, CV Peterson, D Vreugdenhil, DF Calderini, E Nevo, F-X Oury, G Ladizinsky, GA Churchill, GB Gregorio, H Marschner, HE Bouis, Hikmet Budak, I Cakmak, I Cakmak, I Cakmak, I Cakmak, IA Khan, Ismail Cakmak, J Dvořák, JA McVittie, JCR Stangoulis, JL Gonzalez-Hernandez, JN Pearson, JNA Lott, JW Snape, L Avivi, L Gauer, Levent Ozturk, LR Joppa, M Cox, M Feldman, M Feldman, M Prasad, MA Grusak, MR Perretant, N Grotz, PA Sanchez, R Garnett, R Scarth, R Shi, RJ Larsen, RM Welch, RM Welch, S Abbo, S Harjit, S Huang, S McCouch, S Salvi, S Zanetti, SD Tanksley, SH Guzmán-Maldonado, TP O’Brien, Tzion Fahima, V Raboy, V Raboy, W Dijkshoorn, W Zhang, Y Genc, Yan Jun, Yehoshua Saranga, YI Ronin, Z Peleg, Z Peleg, Zvi Peleg   +81 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source