Results 91 to 100 of about 1,208,117 (287)

Novel protein-protein interactions inferred from literature context. [PDF]

PLoS ONE, 2009
We have developed a method that predicts Protein-Protein Interactions (PPIs) based on the similarity of the context in which proteins appear in literature.
Herman H H B M van Haagen, Peter A C 't Hoen, Alessandro Botelho Bovo, Antoine de Morrée, Erik M van Mulligen, Christine Chichester, Jan A Kors, Johan T den Dunnen, Gert-Jan B van Ommen, Silvère M van der Maarel, Vinícius Medina Kern, Barend Mons, Martijn J Schuemie   +12 more
doaj   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A lymphoma plasma membrane-associated protein with ankyrin-like properties. [PDF]

, 1986
In this study we have used several complementary techniques to isolate and characterize a 72-kD polypeptide that is tightly associated with a major mouse T-lymphoma membrane glycoprotein, gp 85 (a wheat germ agglutinin-binding protein), in a 16 S complex.
Balazovich, K, Bourguignon, LY, Suchard, SJ, Walker, G   +3 more
core  

A Multicanonical Molecular Dynamics Study on a Simple Bead-Spring Model for Protein Folding

, 2001
We have performed a multicanonical molecular dynamics simulation on a simple model protein.We have studied a model protein composed of charged, hydrophobic, and neutral spherical bead monomers.Since the hydrophobic interaction is considered to ...
Anfinsen C. B., Berg B. A., Doi M., Erman B., Ferrenberg A. M., Israelachvili J., Levinthal C., Nakajima N., Pande V. S., Saito N., Shea J.-E., Shimizu H., Takeoka Y.   +12 more
core   +1 more source

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Cell, 2016
While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown.
Xinping Yang, J. Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron D. Richardson, Song Sun, Fan Yang, Yun Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, A. MacWilliams, S. Pevzner, Q. Zhong, Shelly A. Trigg, Stanley Tam, L. Ghamsari, Nidhi Sahni, S. Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, M. Costanzo, B. Andrews, Charles Boone, X. Zhou, K. Salehi-Ashtiani, B. Charloteaux, Alyce A. Chen, M. Calderwood, P. Aloy, F. Roth, D. Hill, L. Iakoucheva, Yu Xia, M. Vidal   +37 more
semanticscholar   +1 more source

A Protein Interaction Map of the Mitotic Spindle [PDF]

Molecular Biology of the Cell, 2007
The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604
Wong, Jonathan, Nakajima, Yuko, Westermann, Stefan, Shang, Ching, Kang, Jung-Seog, Goodner, Crystal, Houshmand, Pantea, Fields, Stanley, Chan, Clarence S.M., Drubin, David, Barnes, Georjana, Hazbun, Tony R   +11 more
openaire   +4 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

PEPpip: A Vision-Inspired Explainable Deep Learning Framework for Sequence-Based Protein–Protein Interaction Prediction and Interaction Map Estimation

IEEE Access
Predicting protein–protein interaction (PPI) patterns from primary sequences constitutes a complex pattern recognition task that demands advanced and explainable deep learning frameworks, as PPIs underpin critical cellular and pathological ...
Shubhrangshu Ghosh, Pralay Mitra
doaj   +1 more source

A microtubule interactome: complexes with roles in cell cycle and mitosis.

PLoS Biology, 2008
The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis.
Julian R Hughes, Ana M Meireles, Katherine H Fisher, Angel Garcia, Philip R Antrobus, Alan Wainman, Nicole Zitzmann, Charlotte Deane, Hiroyuki Ohkura, James G Wakefield   +9 more
doaj   +1 more source