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Recent Advances in Protein Homology Detection Propelled by Inter-Residue Interaction Map Threading
Frontiers in Molecular Biosciences, 2021 Sequence-based protein homology detection has emerged as one of the most sensitive and accurate approaches to protein structure prediction. Despite the success, homology detection remains very challenging for weakly homologous proteins with divergent ...
Sutanu Bhattacharya +2 more
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Protein Interaction Maps for Model Organisms
Nature Reviews Molecular Cell Biology, 2001Until recently, classical genetics and biochemistry were the main techniques used to investigate how organisms develop, reproduce, behave and age. But with the availability of complete genome sequences new approaches are emerging. Complete sets of proteins — 'proteomes' — can be predicted from genome sequences and used to characterize protein functions
Marian Walhout, Marc Vidal
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Protein Interaction Maps on the Fly
Nature Biotechnology, 2004A protein interaction map for the fruit fly Drosophila melanogaster promises to facilitate functional analysis of many eukaryotic proteins.
Peter Uetz
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Mapping Protein: Carbohydrate Interactions
Current Protein & Peptide Science, 2003Many biologically important interactions occur between proteins and carbohydrates. The examination of these interactions at the atomic level is critical not only in understanding the nature of these interactions and their biological role, but also in the design of effective modulators of these interactions.
Gerald F, Audette +2 more
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Novel Approaches to Map Protein Interactions
Current Opinion in Biotechnology, 2003Although we now have the sequence of the human genome at hand, we face the challenge of assigning function to the identified genes. Genes usually ascribe their function through proteins, and the role of proteins is to interact with other molecules. Therefore, if we could map the interactions of proteins we would be able to understand protein function ...
Daniel Figeys
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The Protein–Protein Interaction Map of Helicobacter pylori
Nature, 2001With the availability of complete DNA sequences for many prokaryotic and eukaryotic genomes, and soon for the human genome itself, it is important to develop reliable proteome-wide approaches for a better understanding of protein function. As elementary constituents of cellular protein complexes and pathways, protein-protein interactions are key ...
Hilde de Reuse +2 more
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Drosophila Protein Interaction Map (DPiM) [PDF]
Fly, 2012 Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
spyros A-T +2 more
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Mapping Protein–Protein Interactions by Quantitative Proteomics
2010Proteins exert their function inside a cell generally in multiprotein complexes. These complexes are highly dynamic structures changing their composition over time and cell state. The same protein may thereby fulfill different functions depending on its binding partners.
Dengjel, Jörn +2 more
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Mapping of RNA–protein interactions
Analytica Chimica Acta, 2009RNA-protein interactions are important biological events that perform multiple functions in all living organisms. The wide range of RNA interactions demands diverse conformations to provide contacts for the selective recognition of proteins. Various analytical procedures are presently available for quantitative analyses of RNA-protein complexes, but ...
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