Results 241 to 250 of about 8,260,919 (293)

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Targeting BCL-2 through Deep Learning-Based Drug Repurposing: A Multimodal Approach Combining Diffusion-Based Generative Modeling, Neural Relational Inference, and In Vitro Validation. [PDF]

J Chem Inf Model
Sayyah E, Tunç H, Çelebi A, Avşar T, Durdağı S.   +4 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Evolutionary and dynamic constraints converge on a conserved coupling sector in thermally adapted GH1 β-glucosidases. [PDF]

PLoS Comput Biol
Zheng LT, Li Y, He X, Yang LT, Zhao DR, Liu MT, Sang P, Yang LQ.   +7 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

From wireframes to immersive reality: a historical perspective on molecular visualization software. [PDF]

Brief Bioinform
Leitão AL, Enguita FJ.
europepmc   +1 more source

A Systematic Analysis of Lipid-Protein Interactions in the Protein Data Bank. [PDF]

Biochemistry
Puri N, McShan AC.
europepmc   +1 more source

Starch phosphorylase acts as a pivotal scaffold connecting starch metabolism enzymes with photosystem I subunits. [PDF]

Plant Cell Physiol
Hwang SK, Tian L, Ng CY, Okita TW.
europepmc   +1 more source