Results 271 to 280 of about 435,247 (293)

Transcriptome-Wide Mapping of Protein–RNA Interactions

2020
RNA and RNA-binding proteins (RBPs) control multiple biological processes. The spatial and temporal arrangement of RNAs and RBPs underlies the delicate regulation of these processes. The strategy called CLIP-seq (cross-linking and immunoprecipitation) has been developed to capture endogenous protein-RNA interactions with UV cross-linking followed by ...
Xianju, Bi, Xiaohua, Shen
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Mapping protein–protein interactions with combinatorial biology methods

Current Opinion in Biotechnology, 2001
Extremely diverse, DNA-encoded libraries of peptides and proteins have been constructed that include a linkage between each polypeptide and the encoding DNA. Library members can be selected by virtue of a particular binding specificity, and their protein sequence can be deduced from the sequence of the cognate DNA.
J, Pelletier, S, Sidhu
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A Protein Interaction Map of Drosophila melanogaster

Science, 2003
Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid–based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map
L, Giot, J S, Bader, C, Brouwer, A, Chaudhuri, B, Kuang, Y, Li, Y L, Hao, C E, Ooi, B, Godwin, E, Vitols, G, Vijayadamodar, P, Pochart, H, Machineni, M, Welsh, Y, Kong, B, Zerhusen, R, Malcolm, Z, Varrone, A, Collis, M, Minto, S, Burgess, L, McDaniel, E, Stimpson, F, Spriggs, J, Williams, K, Neurath, N, Ioime, M, Agee, E, Voss, K, Furtak, R, Renzulli, N, Aanensen, S, Carrolla, E, Bickelhaupt, Y, Lazovatsky, A, DaSilva, J, Zhong, C A, Stanyon, R L, Finley, K P, White, M, Braverman, T, Jarvie, S, Gold, M, Leach, J, Knight, R A, Shimkets, M P, McKenna, J, Chant, J M, Rothberg   +48 more
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Construction and Prediction of Protein-Protein Interaction Maps

2002
With the completion of full genome sequence for several model organisms, new approaches are emerging to comprehensively characterize the function of gene products. In these so-called functional proteomics approaches, large-scale assays on the complete set of proteins of a given organism — the proteome — enable the study of the function of proteins in ...
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Mapping the interaction site of prion protein and Sho

Molecular Biology Reports, 2009
The cellular prion protein (PrP(C)) is a highly conserved protein among mammals and is considered to have important cellular functions. Despite decades of intensive research, however, the physiological function of PrP(C) remains unclear. Sho (Shadoo, shadow of prion protein) and PrP(C) have similar N-terminals, which suggests that the two proteins ...
Wan, Jiayu, Hao, Zhu, Xu, Ming, Wang, Xiong, Wu, Songbo, Song, Bocui, Liu, Wensen, Li, Jiping, Meng, Keying, Li, Zhongyi, Gao, Hongwei   +10 more
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Mapping protein?protein interactions by bioinformatics and cross-linking

Analytical and Bioanalytical Chemistry, 2004
Protein–protein interactions play a key role in many cellular processes. Determining the protein interaction network is one of the major tasks of functional proteomics. Databases of protein interactions integrate the large amounts of information available on protein– protein interactions, ranging from functional interactions (such as which proteins are
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Mapping Protein−Protein Interactions in Solution by NMR Spectroscopy

Biochemistry, 2001
NMR is very well suited to the study of especially weak protein-protein interactions, as no crystallization is required. The available NMR methods to this end are reviewed and illustrated with applications from the recent biochemical literature: intermolecular NOEs, cross-saturation, chemical shift perturbation, dynamics and exchange perturbation ...
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Visualized heterooligomeric subunit structures of 817 human cellular proteins by correlating native protein 2D maps with protein interaction databases

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2021
Ya Jin, Takashi Manabe
exaly  

Protein-protein interaction mapping of phospholipase

2023
Ananya Samanta, Semanti Ghosh, Angshuman Bagchi   +2 more
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Use of protein-interaction maps to formulate biological questions

Current Opinion in Chemical Biology, 2001
Simon J Boulton, Marc Vidal
exaly