A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, EarlyView.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Substrate preference of protein kinase B isoforms can vary depending on the cell line.
PLoS ONEMany proteins in higher eukaryotes, especially those with crucial functions, have multiple isoforms with redundant roles providing protection against potential functional deficiencies in one isoform.
Miguel S Palma +3 more
doaj +1 more source
Characterizing the Protein Isoforms of foraging (for), the PKGI Ortholog in Drosophila melanogaster. [PDF]
Int J Mol Sci, 2023 Vasquez OE +6 more
europepmc +1 more source
Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating
Advanced Biology, EarlyView.This study explores how magnesium–calcium coatings on titanium promote osteogenesis by releasing ions and elevating pH during degradation. Using osteoblast‐like cells, the research demonstrates that both ion release and pH changes contribute to cell proliferation, differentiation, and mineralization, offering new insights into the design of bioactive ...
Risa Miyake +4 more
wiley +1 more source
Correction: Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]
PLoS One, 2023 Pantaleão SQ +10 more
europepmc +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
C-reactive protein isoforms as prognostic markers of COVID-19 severity. [PDF]
Front Immunol, 2022 Molins B +8 more
europepmc +1 more source
Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus [PDF]
, 2019 Xi Wang +15 more
openalex +1 more source
Utilizing RNA-Seq Data for Cancer Network Inference
, 2012 An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S. +2 more
core +1 more source
Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo
Advanced Functional Materials, EarlyView.This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić +9 more
wiley +1 more source