Results 181 to 190 of about 6,367,317 (393)

Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells [PDF]

, 2003
Xuelian Zhang, Daying Zhang, Frank Michel, Jason L. Blum, Frank A. Simmen, Rosalia C.M. Simmen   +5 more
openalex   +1 more source

Bridging the splicing gap in human genetics with long-read RNA sequencing: finding the protein isoform drivers of disease

, 2022
Peter J. Castaldi, Abdullah Abood, Charles R. Farber, Gloria Sheynkman   +3 more
openalex   +2 more sources

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

Nature Immunology, 2019
Johannes Schwerk, F. Soveg, Andy P Ryan, Kerri R. Thomas, Lauren D Hatfield, Snehal Ozarkar, Adriana Forero, Alison M Kell, J. A. Roby, Lomon So, J. Hyde, M. Gale, M. Daugherty, R. Savan   +13 more
semanticscholar   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases. [PDF]

Front Chem, 2022
Oliva F, Musiani F, Giorgetti A, De Rubeis S, Sorokina O, Armstrong DJ, Carloni P, Ruggerone P.   +7 more
europepmc   +1 more source

Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor‐2 in cardiovascular development and disease

, 2008
Siyun Liao, Janet R. Bodmer, Daniel Anthony Pietras, Mohamad Azhar, Tom Doetschman, Jo El J. Schultz   +5 more
openalex   +2 more sources

Isoform of Bruton's tyrosine kinase (BTK) protein

, 2008
The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR ...
LAVITRANO, MARIALUISA, GRASSILLI, EMANUELA, Helin, K.   +2 more
openaire   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain

Genome Biology
Background Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes.
Ricardo De Paoli-Iseppi, Shweta S. Joshi, Josie Gleeson, Yair D. J. Prawer, Yupei You, Ria Agarwal, Anran Li, Anthea Hull, Eloise M. Whitehead, Yoonji Seo, Rhea Kujawa, Raphael Chang, Mriga Dutt, Catriona McLean, Benjamin L. Parker, Michael B. Clark   +15 more
doaj   +1 more source

Lyssavirus P Protein Isoforms Diverge Significantly in Subcellular Interactions Underlying Mechanisms of Interferon Antagonism. [PDF]

J Virol, 2022
Brice AM, Rozario AM, Rawlinson SM, David CT, Wiltzer-Bach L, Jans DA, Ito N, Bell TDM, Moseley GW.   +8 more
europepmc   +1 more source