Results 251 to 260 of about 6,367,317 (393)

A-to-I mRNA editing recodes hundreds of genes in dozens of species and produces endogenous protein isoforms in bacteria. [PDF]

Nucleic Acids Res
Elias E, Gifford I, Didi L, Fargeon O, Arad D, Cohen-Pavon R, Sorek G, Levin L, Melamed D, Aspit L, Barrick JE, Bar-Yaacov D.   +11 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Identification and characterization of human KALRN mRNA and Kalirin protein isoforms. [PDF]

Cereb Cortex
Mould AW, Wright DJ, Bornemann KD, Hengerer B, Pinnock R, Drydale E, Bancroft J, Hall NAL, von Delft A, Brennan PE, Harrison PJ, Haerty W, Tunbridge EM.   +12 more
europepmc   +1 more source

Truncated WT1 protein isoform expression is increased in MCF-7 cells in a long-term estrogen depletion [PDF]

, 2019
Santiago Saavedra-Alonso, Pablo Zapata‐Benavides, Edgar Mendoza-Gamboa, Chavez-Escamilla Ana Karina, Mariela Arellano-Rodríguez, Rodriguez-Padilla Cristina   +5 more
openalex   +1 more source

Myelin management by the 18.5‐kDa and 21.5‐kDa classic myelin basic protein isoforms

Journal of Neurochemistry, 2013
G. Harauz, J. Boggs
semanticscholar   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures. [PDF]

Nucleic Acids Res
Yang Y, Kumar H, Xie Y, Li Z, Li R, Chen W, Diala CS, Ali MA, Xu Y, Wu A, Hosseini SR, Bi E, Zhao H, Kim P, Zheng WJ.   +14 more
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction. [PDF]

Nucleic Acids Res
Vukić D, Cherian A, Keskitalo S, Bong YT, Marônek M, Yadav L, Keegan LP, Varjosalo M, O'Connell MA.   +8 more
europepmc   +1 more source

A ratiometric catalog of protein isoform shifts in the cardiac fetal gene program [PDF]

Yu Han, Shaonil Binti, Sara A. Wennersten, Boomathi Pandi, Dominic C. M. Ng, Edward Lau, Maggie P. Y. Lam   +6 more
openalex   +1 more source