Results 1 to 10 of about 2,092,635 (263)
Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia [PDF]
Journal of Biological Chemistry, 2016 Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance.
Roth Flach, Rachel J. +12 more
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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]
Journal of Biological Chemistry, 2005 The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Rebecca L, Hurley +5 more
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Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci +2 more
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A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]
, 1988 A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
A.M. Edelman +34 more
core +1 more source
The many-faced KSR1: a tumor suppressor in breast cancer [PDF]
, 2015 Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2].
Giamas, Georgios +2 more
core +2 more sources
The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]
, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel +8 more
core +3 more sources
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]
, 1999 Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden +25 more
core +1 more source
Current Biology, 2015 Soppa and Becker introduce the DYRK family of dual specificity protein kinases and their diverse functions and associations with genetic diseases.
Soppa, Ulf, Becker, Walter
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IUBMB Life, 2000 Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
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Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]
, 2017 c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie +15 more
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