Results 221 to 230 of about 2,248,467 (361)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Knockdown of Serine-Arginine Protein Kinase 3 Impairs Sperm Development in <i>Spodoptera frugiperda</i>. [PDF]

Insects
Song Y, Zhou Y, Wang R, Zhang B, Li Z, Liu X, Li D.   +6 more
europepmc   +1 more source

Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes [PDF]

, 1997
Guillermo Velasco, Manuel Guzmán, Victor A. Zammit, Math J.H. Geelen   +3 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer. [PDF]

Oncol Rep
Leung RC, Liu SS, Chan KY, Tam KF, Chan KL, Wong LC, Ngan HY.   +6 more
europepmc   +1 more source

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

, 2018
Zi-Han Tian, Jueng-Tsueng Weng, Li‐Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei, Yow-Chii Kuo, Tsu-Shing Wang, Yung-Hsi Kao   +8 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Protein kinase GIα oxidation negatively regulates antibody production by B cells. [PDF]

Redox Biol
Cho HJ, Charles RL, Prysyazhna O, Arjun S, Francois AA, McBride KM, Eaton P.   +6 more
europepmc   +1 more source

Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells.

, 1993
Michael E. Ottlinger, Laurie Pukac, Morris J. Karnovsky   +2 more
openalex   +1 more source

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans [PDF]

, 2018
Stefan Lutz, Mathias Falcenberg, Fausto Machicao, Andreas Peter, Martin Kächele, Elko Randrianarisoa, Angela Lehn‐Stefan, Róbert Wágner, Jürgen Machann, Fritz Schick, Martin Heni, Axel Ullrich, Andreas Fritsche, Norbert Stefan, Hans‐Ulrich Häring, Harald Staiger, Kοnstantinos Kantartzis   +16 more
openalex   +1 more source