A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis. [PDF]
BiomedicinesBackground: Protein kinase D3 (PKD3) is a member of the PKD family that has been implicated in many intracellular signalling pathways. However, defined statements regarding PKD isoform specificity and in vivo functions are rare.
Braun U, Leitges M.
europepmc +2 more sources
Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
doaj +1 more source
The Kinase Specificity of Protein Kinase Inhibitor Peptide
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj +1 more source
Role of adenosine triphosphate and protein kinase A in the force-frequency relationship in isolated rat cardiomyocytes [PDF]
Archives of Biological Sciences, 2023 The physiological heart rate of rodents is around 4-6 Hz, although a stimulus frequency of 1 Hz is generally used in isolated cardiomyocytes to study changes in the contraction-relaxation cycle in cardiac muscle physiology and pathophysiology.
Ozturk Nihal +3 more
doaj +1 more source
Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction
Cells, 2021 Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation to various extracellular stimuli.
Anne-Sophie Colombe, Guillaume Pidoux
doaj +1 more source
Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway [PDF]
International Journal of Ophthalmology, 2020 AIM: To test our hypothesis that activation of protein kinase A (PKA) signal pathway by β-adrenergic agonist plays an important role in the protecting of cultured retinal pigment epithelial (RPE) cells against the hydroxychloroquine (HCQ) toxicity ...
Ruihua Zhang, Dan-Ning Hu, Richard Rosen
doaj +1 more source
A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling
Cells, 2023 The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper ...
Hariharan Subramanian +1 more
doaj +1 more source
Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Glioma is one of the common intracranial malignant tumors, but the specific mechanism was unclear. The expression level of choline kinase A (CHKA) is positively correlated with the malignant grade of glioma.
HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
doaj +1 more source
A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction
Cells, 2021 Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric +5 more
doaj +1 more source
Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A
Frontiers in Physiology, 2020 The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu +4 more
doaj +1 more source