The Kinase Specificity of Protein Kinase Inhibitor Peptide [PDF]
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
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A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis [PDF]
BiomedicinesBackground: Protein kinase D3 (PKD3) is a member of the PKD family that has been implicated in many intracellular signalling pathways. However, defined statements regarding PKD isoform specificity and in vivo functions are rare.
Ursula Braun, Michael Leitges
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Exploring the differential localization of protein kinase A isoforms in Candida albicans [PDF]
mSphereThe cAMP-dependent protein kinase A (PKA) plays important roles in a wide range of biological processes in eukaryotic organisms. In the fungal pathogen Candida albicans, PKA is a critical regulator of morphological transitions, which are a key virulence ...
Saif Hossain +3 more
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Protein Kinases in Leukemias [PDF]
Cancers, 2021 Protein kinases (PK) make up around 2% of the human genome and their expression profile varies depending on the organ and tissue [...]
Paulo De Sepulveda, Jean-Max Pasquet
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Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
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Role of adenosine triphosphate and protein kinase A in the force-frequency relationship in isolated rat cardiomyocytes [PDF]
Archives of Biological Sciences, 2023 The physiological heart rate of rodents is around 4-6 Hz, although a stimulus frequency of 1 Hz is generally used in isolated cardiomyocytes to study changes in the contraction-relaxation cycle in cardiac muscle physiology and pathophysiology.
Ozturk Nihal +3 more
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Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction
Cells, 2021 Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation to various extracellular stimuli.
Anne-Sophie Colombe, Guillaume Pidoux
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Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway [PDF]
International Journal of Ophthalmology, 2020 AIM: To test our hypothesis that activation of protein kinase A (PKA) signal pathway by β-adrenergic agonist plays an important role in the protecting of cultured retinal pigment epithelial (RPE) cells against the hydroxychloroquine (HCQ) toxicity ...
Ruihua Zhang, Dan-Ning Hu, Richard Rosen
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The concentration of androgen receptor and protein kinase A in male chicken following the administration of a combination of the epididymis and testicular extracts [PDF]
Veterinary World, 2020 Background and Aim: Testis (T) and epididymis (E) are waste from the abattoir that is rarely used. In fact, both organs contain important chemicals needed for spermatogenesis (e.g., hormones, proteins, and other molecules). Therefore, administration of a
Muslim Akmal +6 more
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Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Glioma is one of the common intracranial malignant tumors, but the specific mechanism was unclear. The expression level of choline kinase A (CHKA) is positively correlated with the malignant grade of glioma.
HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
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