Results 21 to 30 of about 1,326,529 (167)
Sensors, 2010 The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges.
Joseph R. Burgoyne, Philip Eaton
doaj +1 more source
Biomedicines, 2021 We propose a simple label-free electrochemical biosensor for monitoring protein kinase activity and inhibition using a peptide-modified electrode. The biosensor employs cys-kemptide (CLRRASLG) as a substrate peptide which was immobilized on the surface ...
Hyunju Cho, Chang-Seuk Lee, Tae Hyun Kim
doaj +1 more source
Protein Kinases as Drug Development Targets for Heart Disease Therapy
Pharmaceuticals, 2010 Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease.
Alison L. Müller, Naranjan S. Dhalla
doaj +1 more source
The Role of Cyclic AMP Signaling in Cardiac Fibrosis
Cells, 2019 Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay +3 more
doaj +1 more source
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
eLife, 2023 Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood.
Gary KL Chan +19 more
doaj +1 more source
Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]
Scripta Medica, 2023 Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad +4 more
doaj
eLife, 2022 Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture.
Komal Ramani +6 more
doaj +1 more source
Biology Open, 2017 Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
doaj +1 more source
Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
eLife, 2022 Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial.
Juan Qin +8 more
doaj +1 more source
Interaction of AIP with protein kinase A (cAMP-dependent protein kinase) [PDF]
Human Molecular Genetics, 2018 Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene cause mostly somatotropinomas and/or prolactinomas in a subset of familial isolated pituitary adenomas (FIPA). AIP has been shown to interact with phosphodiesterases (PDEs) and G proteins, suggesting a link to the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Marie Helene, Schernthaner-Reiter +2 more
openaire +2 more sources