Results 21 to 30 of about 2,670,458 (365)
Sensors, 2010 The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges.
Joseph R. Burgoyne, Philip Eaton
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Metabolic Kinases Moonlighting as Protein Kinases [PDF]
Trends in Biochemical Sciences, 2018 Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin Lu, Zhimin Lu, Tony Hunter
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IUBMB Life, 2000 Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
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Biomedicines, 2021 We propose a simple label-free electrochemical biosensor for monitoring protein kinase activity and inhibition using a peptide-modified electrode. The biosensor employs cys-kemptide (CLRRASLG) as a substrate peptide which was immobilized on the surface ...
Hyunju Cho, Chang-Seuk Lee, Tae Hyun Kim
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Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]
Journal of Biological Chemistry, 2005 (R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S. +21 more
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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America, 2000 Glycogen synthase kinase 3 (GSK-3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. GSK-3 activity is inhibited through phosphorylation of serine 21 in GSK-3 alpha
Xianjun Fang +5 more
semanticscholar +1 more source
Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Jack E. Dixon +3 more
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Protein Kinases as Drug Development Targets for Heart Disease Therapy
Pharmaceuticals, 2010 Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease.
Alison L. Müller, Naranjan S. Dhalla
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Role of AMP-activated protein kinase in mechanism of metformin action.
Journal of Clinical Investigation, 2001 Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects
Gaochao Zhou +13 more
semanticscholar +1 more source
Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]
Scripta Medica, 2023 Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad +4 more
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