Results 201 to 210 of about 79,392 (254)

Nerandomilast alleviates myositis-associated interstitial lung disease by modulating the non-Smad signalling pathway and activating the cAMP-PKA-RhoA pathway. [PDF]

RMD Open
Cui X, Li W, Chai H, Jiang Y, Guo J, Yang J, Zhu J, Zhang S.   +7 more
europepmc   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Unpredictable sound stress induces a novel form of hyperalgesic priming. [PDF]

Pain
Araldi D, Green PG, Levine JD.
europepmc   +1 more source

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, Volume 159, Issue 4, Page 936-950, 15 August 2026.
What's new? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Pregabalin Depresses Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission by Modulating Glun2a-Containing Nmda Receptors in Mice In Vitro. [PDF]

Int J Mol Sci
Li MR, Zhang XD, Chen L, Zhang YD, Wang CY, Zhao ZY, Zhou M, Chu CP, Qiu DL.   +8 more
europepmc   +1 more source

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner.

Development, 2016
Nedvetsky PI, Zhao X, Mathivet T, Aspalter IM, Stanchi F, Metzger RJ, Mostov KE, Gerhardt H.   +7 more
europepmc   +1 more source

PAK4 in metabolic diseases: regulation by nutrient signals and therapeutic implications. [PDF]

Exp Mol Med
Bang IH, Park BH, Bae EJ.
europepmc   +1 more source

Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway. [PDF]

Nat Struct Mol Biol
Steiner WP, Iverson N, Liu G, Venkatakrishnan V, Wu J, Stepniewski TM, Michaelson Z, Bröckel JW, Zhu JF, Bruystens JGH, Lee A, Nelson I, Bertinetti D, Arveseth CD, Tan G, Spaltenstein P, Xu J, Hüttenhain R, Kay MS, Herberg FW, Cao E, Selent J, Anand GS, Dunbrack RL, Taylor SS, Myers BR.   +25 more
europepmc   +1 more source

GLP-1 receptor and Mitochondria-ER Contact Sites: an emerging mechanism of metabolic regulation. [PDF]

Front Physiol
Cruz P, Puebla-Huerta A, Troncoso MF, Silva-Pavez E, Hidalgo-Fadic Y, Ahumada-Castro U.   +5 more
europepmc   +1 more source