Interaction of AIP with protein kinase A (cAMP-dependent protein kinase). [PDF]
Hum Mol Genet, 2018 Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene cause mostly somatotropinomas and/or prolactinomas in a subset of familial isolated pituitary adenomas (FIPA). AIP has been shown to interact with phosphodiesterases (PDEs) and G proteins, suggesting a link to the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Schernthaner-Reiter MH +2 more
europepmc +4 more sources
Probes of the mitochondrial cAMP-dependent protein kinase. [PDF]
Biochim Biophys Acta, 2013 The development of a fluorescent assay to detect activity of the mitochondrial cAMP-dependent protein kinase (PKA) is described. A peptide-based sensor was utilized to quantify the relative amount of PKA activity present in each compartment of the mitochondria (the outer membrane, the intermembrane space, and the matrix).
Shell JR, Lawrence DS.
europepmc +4 more sources
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. [PDF]
PLoS ONE, 2017 The 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase, or protein kinase A (PKA), pathway is one of the most versatile and best studied signaling pathways in eukaryotic cells.
Kristoffer Søberg +3 more
doaj +2 more sources
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase [PDF]
Proceedings of the National Academy of Sciences, 1998 Although phosphorylation of Thr-197 in the activation loop of the catalytic subunit of cAMP-dependent protein kinase (PKA) is an essential step for its proper biological function, the kinase responsible for this reaction in vivo has remained elusive.
X, Cheng +4 more
openaire +3 more sources
Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease [PDF]
LifeProtein kinase A (PKA) is a key regulator of cellular signaling that regulates key physiological processes such as metabolism, cell proliferation, and neuronal function.
Ese S. Ekhator +2 more
doaj +2 more sources
Topology of the mitochondrial cAMP-dependent protein kinase and its substrates [PDF]
FEBS Letters, 1996 In intact bovine heart mitochondria, cAMP‐dependent phosphorylation of 42, 29, 18 and 6.5 kDa proteins was inhibited by carboxyatractyloside. This shows that both mitochondrial cAMP‐dependent protein kinase (mtPKA) and its protein substrates are localized at the matrix side of the inner mitochondrial membrane.
Sergio Papa +2 more
exaly +4 more sources
Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. [PDF]
Cell Chem Biol, 2018 O'Banion CP +5 more
europepmc +2 more sources
Journal of Fungi, 2022 Morphogenesis is a strictly regulated efficient system in eukaryotes for adapting to environmental changes. However, the morphogenesis regulatory mechanism in smut fungi is not clear.
Enping Cai +7 more
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Molecular Basis for Ser/Thr Specificity in PKA Signaling
Cells, 2020 cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this
Matthias J. Knape +7 more
doaj +1 more source
Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma. [PDF]
PLoS ONE, 2016 The association of pathological features of cortisol-producing adrenocortical adenomas (ACAs) with somatic driver mutations and their molecular classification remain unclear.
Weiwei Zhou +9 more
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