Results 11 to 20 of about 6,565,578 (347)

Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice. [PDF]

Adv Sci (Weinh)
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Yao L, Hatami M, Koc S, Jiang Q, Skutella T, Zhang Y.   +5 more
europepmc   +2 more sources

Mechanisms of adrenocorticotropin-induced activation of erk 1/2 map kinase in the human H295R adrenal cell line [PDF]

, 2008
PhDThe role of ACTH in stimulating or inhibiting growth of adrenal cells has been a subject of some controversy. Reports that ACTH may stimulate Erk/MAP kinase in Y1 cells have suggested a role for cAMP in this process.
Janes, Mandy Elaine
core   +4 more sources

Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner

Endocrine Regulations, 2020
Objective. The aim of this investigation was to study the expression of genes encoding cAMP-activated protein kinase catalytic and regulatory A subunits (PRKACA and PRKAR1A) and related proteins such as cAMP-dependent protein kinase inhibitors A and G ...
Ratushna Oksana O.
doaj   +1 more source

cAMP-Dependent Protein Kinase Activity in Yeast Mitochondria [PDF]

Zeitschrift für Naturforschung C, 1987
Two different cAMP-binding proteins have been identified in yeast mitochondria by photo­ affinity labelling and based on the occurrence of cAMP-binding activity in two different sub-mito­ chondrial fractions. One protein (Mr 45-46000) is tightly bound to the inner mitochondrial membrane whereas the other (Mr 42000) is found in the soluble intermembrane
Müller, Günter, Bandlow, Wolfhard
openaire   +3 more sources

Activation of adenosine 3‘,5‘-monophosphate-dependent protein kinase and its relationship to cyclic AMP and lipolysis in hamster adipose tissue.

Journal of Lipid Research, 1980
The interrelationships among cAMP-dependent protein kinase activity, lipolysis, and cellular concentrations of cAMP were investigated in hamster epididymal adipose tissue.
R J Schimmel, C A Buhlinger, R Serio
doaj   +1 more source

cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Plasmodium falciparum Blood Stages

Frontiers in Microbiology, 2021
We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in particular, the importance of the second messengers, cAMP and Ca2+, and cyclic nucleotide ...
Edwin Lasonder, Kunal More, Shailja Singh, Malak Haidar, Malak Haidar, Daniela Bertinetti, Eileen J. Kennedy, Friedrich W. Herberg, Anthony A. Holder, Gordon Langsley, Gordon Langsley, Chetan E. Chitnis   +11 more
doaj   +1 more source

Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose. [PDF]

PLoS ONE, 2012
The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP.
Andreas Hammerschmidt, Bijon Chatterji, Johannes Zeiser, Anke Schröder, Hans-Gottfried Genieser, Andreas Pich, Volkhard Kaever, Frank Schwede, Sabine Wolter, Roland Seifert   +9 more
doaj   +1 more source

Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase

Journal of Neuroscience, 2000
Modulation of postsynaptic AMPA receptors in the brain by phosphorylation may play a role in the expression of synaptic plasticity at central excitatory synapses.
T. Banke, D. Bowie, Hey-Kyoung Lee, R. Huganir, A. Schousboe, S. Traynelis   +5 more
semanticscholar   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

Folding and activity of cAMP‐dependent protein kinase mutants [PDF]

FEBS Letters, 2005
The catalytic subunit of cAMP‐dependent protein kinase (PKA) can easily be expressed in Escherichia coli and is catalytically active. Four phosphorylation sites are known in PKA (S10, S139, T197 and S338), and the isolated recombinant protein is a mixture of different phosphorylated forms.
Langer, Thomas, Sreeramulu, Sridhar, Vogtherr, Martin, Elshorst, Bettina, Betz, Marco, Schieborr, Ulrich, Saxena, Krishna, Schwalbe, Harald   +7 more
openaire   +2 more sources