Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits. [PDF]
PLoS ONE, 2013 3',5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in eukaryotic cells.
Kristoffer Søberg +4 more
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Journal of Biological Chemistry, 1992 Postsynaptic densities (PSD) are a network of proteins located on the internal surface of excitatory synapses just inside the postsynaptic membrane. Enzymes associated with the PSD are optimally positioned to respond to signals transduced across the ...
D. W. Carr +4 more
semanticscholar +1 more source
Control of PKA stability and signalling by RING ligase praja2 [PDF]
, 2010 Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: Dietary supplementation with L-arginine (Arg) has been shown to increase the volume of fetal fluids in gestating swine. Aquaporins (AQPs), known as water channel proteins, are essential for embryonic growth and development.
Cui Zhu +8 more
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Cell Communication and Signaling, 2019 Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation.
Stephanie Makhoul +6 more
doaj +1 more source
Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. [PDF]
PLoS ONE, 2011 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange.
Hui-Chi Lai +7 more
doaj +1 more source
Extracellular regulation of sperm transmembrane adenylyl cyclase by a forward motility stimulating protein. [PDF]
PLoS ONE, 2014 Forward motility stimulating factor (FMSF), a glycoprotein isolated from buffalo serum, binds to the surface of the mature sperm cells to promote their progressive motility.
Souvik Dey +3 more
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Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]
, 1994 The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen +5 more
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Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling
Molecules, 2022 Melanin pigment produced in melanocytes plays a protective role against ultraviolet radiation. Selective destruction of melanocytes causes chronic depigmentation conditions such as vitiligo, for which there are very few specific medical treatments. Here,
Sun Young Moon +7 more
doaj +1 more source
Proteolytic Regulation of the Mitochondrial cAMP-Dependent Protein Kinase [PDF]
Biochemistry, 2012 The mitochondrial cAMP-dependent protein kinase (PKA) is activatable in a cAMP-independent fashion. The regulatory (R) subunits of the PKA holoenzyme (R2C2), but not the catalytic (C) subunits, suffer proteolysis upon exposure of bovine heart mitochondria to digitonin, Ca2+, and a myriad of electron transport inhibitors.
Jennifer R, Shell, David S, Lawrence
openaire +2 more sources