Results 51 to 60 of about 6,565,578 (347)

Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation

open access: yesFrontiers in Molecular Neuroscience, 2018
Cyclic adenosine 3′,5′monophosphate (cAMP) regulated element binding protein (CREB) is a transcription factor involved in many different signaling processes including memory storage and retrieval.
Erik Maronde
doaj   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

open access: yes, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat   +16 more
core   +1 more source

Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-α release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors

open access: yesMediators of Inflammation, 1996
We investigated the effects of specific inhibitors of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) on the inhibitory activity of phosphodiesterase (PDE) type 4 inhibitors and of the cell permeable analogue of cAMP, db-cAMP ...
A. Hichami   +5 more
doaj   +1 more source

Involvement of cAMP-dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation.

open access: yesDevelopmental Biology, 1986
We report the results of experiments which support the hypothesis that, in mouse oocytes, a decrease in intraoocyte cyclic AMP (cAMP) initiates meiotic maturation; oocytes microinjected with cyclic nucleotide phosphodiesterase (PDE) underwent germinal ...
E. Bornslaeger, P. Mattei, R. M. Schultz
semanticscholar   +1 more source

Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]

open access: yes, 2010
The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core   +1 more source

Regulation of Cardiac PKA Signaling by cAMP and Oxidants

open access: yesAntioxidants, 2021
Pathologies, such as cancer, inflammatory and cardiac diseases are commonly associated with long-term increased production and release of reactive oxygen species referred to as oxidative stress.
Friederike Cuello   +4 more
doaj   +1 more source

Drosophila cAMP-dependent protein kinase.

open access: yesJournal of Biological Chemistry, 1984
cAMP-dependent protein kinase has been purified to homogeneity from adult bodies of Drosophila melanogaster. It is tetrameric in structure with two regulatory and two catalytic subunits that dissociate when activated by cAMP. The regulatory subunit exists in phospho and dephospho forms, which have electrophoretic mobilities in sodium dodecyl sulfate ...
J L, Foster   +3 more
openaire   +2 more sources

Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium.

open access: yesJournal of Biological Chemistry, 1991
A protein of apparent Mr = 15,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis is the major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. In the work described
Cathy J. Palmer, B. Scott, L. R. Jones
semanticscholar   +1 more source

Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors [PDF]

open access: yes, 2002
GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the ...
Trevor G Smart   +7 more
core  

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. [PDF]

open access: yes, 2015
GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM   +5 more
core   +1 more source

Home - About - Disclaimer - Privacy