Results 61 to 70 of about 6,565,578 (347)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP

Cells, 2019
Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith, Andrew C. Newby, Mark Bond   +2 more
doaj   +1 more source

Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cells. [PDF]

PLoS ONE, 2012
Luteolin (3',4',5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity to promote neuronal survival and neurite outgrowth.
Lian-Fang Lin, Szu-Ping Chiu, Ming-Jiuan Wu, Pei-Yi Chen, Jui-Hung Yen   +4 more
doaj   +1 more source

Regulation of cAMP-dependent Protein Kinase Activity by Glutathionylation [PDF]

Journal of Biological Chemistry, 2002
The catalytic subunit of cAMP-dependent protein kinase (cAPK) is susceptible to inactivation by a number of thiol-modifying reagents. Inactivation occurs through modification of cysteine 199, which is located near the active site. Because cysteine 199 is reactive at physiological pH, and modification of this site inhibits activity, we hypothesized that
Kenneth M, Humphries, Celina, Juliano, Susan S, Taylor   +2 more
openaire   +2 more sources

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

Biochimica et Biophysica Acta, 2008
The catalytic subunit of cAMP-dependent protein kinase has served as a prototype for the protein kinase superfamily for many years while structures of the cAMP-bound regulatory subunits have defined the conserved cyclic nucleotide binding (CNB) motif. It
Susan S. Taylor, Choel Kim, Cecilia Y. Cheng, Simon H. J. Brown, Jian Wu, N. Kannan   +5 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Nature Communications, 2019
Protein kinase A (PKA) is a cyclic nucleotide dependent protein kinase. Here the authors use single molecule optical tweezers and steered molecular dynamic simulations to follow in real time and quantitatively characterize the signals transduced by cAMP ...
Yuxin Hao, Jeneffer P. England, Luca Bellucci, Emanuele Paci, H. Courtney Hodges, Susan S. Taylor, Rodrigo A. Maillard   +6 more
doaj   +1 more source

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Journal of Lipid Research, 2013
Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of ...
Kai Cai, Marion B. Sewer
doaj   +1 more source

Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase [PDF]

, 2007
The uptake and processing of nutrients is highly regulated. Cells adapt to changes of the availability of nutrients to provide a complete set of transporters and metabolizing enzymes for optimal use of the available nutrients.
Gander, Stefan
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source