Results 1 to 10 of about 3,578,802 (353)

Protein Kinase C: Targets to Regenerate Brain Injuries? [PDF]

Frontiers in Cell and Developmental Biology, 2019
Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural stem cells (NSC), neuronal ...
Noelia Geribaldi-Doldán, Noelia Geribaldi-Doldán, Ricardo Gómez-Oliva, Ricardo Gómez-Oliva, Samuel Domínguez-García, Samuel Domínguez-García, Pedro Nunez-Abades, Pedro Nunez-Abades, Carmen Castro, Carmen Castro   +9 more
doaj   +6 more sources

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription [PDF]

Journal of Biological Chemistry, 2002
Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes through the regulatory sequence termed antioxidant response element (ARE).
H.-C. Huang, Truyen Nguyen, Cecil B. Pickett   +2 more
openalex   +2 more sources

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm [PDF]

Biochemical Journal, 2003
Alexandra C. Newton
openalex   +2 more sources

Phorbol diester receptor copurifies with protein kinase C.

Proceedings of the National Academy of Sciences of the United States of America, 1983
J E Niedel, L J Kuhn, G R Vandenbark
openalex   +3 more sources

Targeting Protein Kinase C in Glioblastoma Treatment

Biomedicines, 2021
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis
Noelia Geribaldi-Doldán, Irati Hervás-Corpión, Ricardo Gómez-Oliva, Samuel Domínguez-García, Félix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal, Ricardo Pardillo-Díaz, José L. Gil-Salú, Pedro Nunez-Abades, Luis M. Valor, Carmen Castro   +11 more
doaj   +1 more source

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj   +1 more source

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. [PDF]

PLoS ONE, 2012
Pancreatic acinar-to-ductal metaplasia (ADM) is associated with an increased risk of pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma.
Michele L Scotti, Kristin E Smith, Amanda M Butler, Shelly R Calcagno, Howard C Crawford, Michael Leitges, Alan P Fields, Nicole R Murray   +7 more
doaj   +1 more source

Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Pharmacology, 2021
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure.
Lotta Pohjolainen, Julia Easton, Reesha Solanki, Heikki Ruskoaho, Virpi Talman   +4 more
doaj   +1 more source

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Journal of Lipid Research, 2015
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese   +3 more
doaj   +1 more source

Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma

BMC Cancer, 2019
Background Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development.
Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho, Min-Kyung Yeo   +7 more
doaj   +1 more source