Results 1 to 10 of about 3,531,225 (263)

Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes [PDF]

, 1987
Insulin was found to increase protein kinase C activity in BC3H-1 myocytes as determined by in vitro phosphorylation of both a lysine-rich histone fraction (histone III-S) and vinculin.
Cooper, Denise R., de Ruiz Galaretta, Carlos M., Fanjul, Luisa F., Farese, Robert V., Mojsilovic, Ljubomir, Pollet, Robert J., Standaert, Mary L.   +6 more
core   +3 more sources

Targeting Protein Kinase C in Glioblastoma Treatment

Biomedicines, 2021
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis
Noelia Geribaldi-Doldán, Irati Hervás-Corpión, Ricardo Gómez-Oliva, Samuel Domínguez-García, Félix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal, Ricardo Pardillo-Díaz, José L. Gil-Salú, Pedro Nunez-Abades, Luis M. Valor, Carmen Castro   +11 more
doaj   +1 more source

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj   +1 more source

Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Pharmacology, 2021
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure.
Lotta Pohjolainen, Julia Easton, Reesha Solanki, Heikki Ruskoaho, Virpi Talman   +4 more
doaj   +1 more source

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. [PDF]

PLoS ONE, 2012
Pancreatic acinar-to-ductal metaplasia (ADM) is associated with an increased risk of pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma.
Michele L Scotti, Kristin E Smith, Amanda M Butler, Shelly R Calcagno, Howard C Crawford, Michael Leitges, Alan P Fields, Nicole R Murray   +7 more
doaj   +1 more source

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
April P. Kelly, Balendran, Brandlin, C. David Wood, Collins, Czerwinski, Doreen A. Cantrell, Dutil, Edwards, Gao, Hinton, Hinton, Lawlor, LeGood, Matthews, Matthews, Matthews, McManus, Mora, Mora, Pracht, Rey, Rozengurt, Sharon A. Matthews, Sonnenburg, Stempka, Stempka, Storz, Wang, Williams   +29 more
core   +3 more sources

Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma

BMC Cancer, 2019
Background Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development.
Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho, Min-Kyung Yeo   +7 more
doaj   +1 more source

A plant homologue to mammalian brain 14-3-3 protein and protein kinase C inhibitor [PDF]

, 1992
We have isolated cDNA clones of Spinacea oleracea L. and Oenothera hookeri of 930 and 1017 base pairs, respectively. The open reading frame deduced from the Oenothera sequence codes for a protein of a calculated molecular mass of 29 200.
Aitken, Alastair Aitken, Ansorge, Boston, Elliot, Ichimura, Jürgen Soll, Laemmli, Lawton, Parker, Sanger, Stephan Hirsch, Toker, Towbin, Uwe Bertsch, Yamauchi, Young   +16 more
core   +1 more source

Nuclear protein kinase C isoforms and apoptosis

European Journal of Histochemistry, 2009
The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis.
AM Martelli, G Mazzotti, S Capitani
doaj   +1 more source

In-silico genome wide analysis of Mitogen activated protein kinase kinase kinase gene family in C. sinensis

PLoS ONE, 2021
Mitogen activated protein kinase kinase kinase (MAPKKK) form the upstream component of MAPK cascade. It is well characterized in several plants such as Arabidopsis and rice however the knowledge about MAPKKKs in tea plant is largely unknown.
Abhirup Paul, Anurag P. Srivastava, Shreya Subrahmanya, Guoxin Shen, Neelam Mishra   +4 more
doaj   +2 more sources