Results 1 to 10 of about 3,523,322 (409)

Targeting Protein Kinase C in Glioblastoma Treatment

Biomedicines, 2021
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis
Noelia Geribaldi-Doldán, Irati Hervás-Corpión, Ricardo Gómez-Oliva, Samuel Domínguez-García, Félix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal, Ricardo Pardillo-Díaz, José L. Gil-Salú, Pedro Nunez-Abades, Luis M. Valor, Carmen Castro   +11 more
doaj   +1 more source

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj   +1 more source

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. [PDF]

PLoS ONE, 2012
Pancreatic acinar-to-ductal metaplasia (ADM) is associated with an increased risk of pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma.
Michele L Scotti, Kristin E Smith, Amanda M Butler, Shelly R Calcagno, Howard C Crawford, Michael Leitges, Alan P Fields, Nicole R Murray   +7 more
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Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Pharmacology, 2021
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure.
Lotta Pohjolainen, Julia Easton, Reesha Solanki, Heikki Ruskoaho, Virpi Talman   +4 more
doaj   +1 more source

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Journal of Lipid Research, 2015
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese   +3 more
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Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma

BMC Cancer, 2019
Background Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development.
Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho, Min-Kyung Yeo   +7 more
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Mechanisms for redox-regulation of protein kinase C

Frontiers in Pharmacology, 2015
Protein kinase C (PKC) is comprised of a family of signal-regulated enzymes that play pleiotropic roles in the control of many physiological and pathological responses.
Susan F. Steinberg
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Nuclear protein kinase C isoforms and apoptosis

European Journal of Histochemistry, 2009
The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis.
AM Martelli, G Mazzotti, S Capitani
doaj   +1 more source

Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]

, 2012
Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...
Alexandra K. Walker, Beckman, Bernstein, Breslin, Breslin, Brodsky, Buck, Buck, Caldecott, Caldecott, Chappell, Christopher A. Walsh, Date, Dingwall, Dobson, Edward C. Gilmore, El-Khamisy, Evans, Garces, Hsiang, Interthal, John J. Reynolds, Karimi-Busheri, Keith W. Caldecott, Koch, Kouzminova, Kuzminov, Lee, Lindahl, Loizou, McCullough, Moreira, Riballo, Segal-Raz, Shen, Sprules, Takashima, Wang, Wang, Ward, Ward, Whitehouse   +41 more
core   +1 more source