Results 31 to 40 of about 22,579,147 (304)
Protein Kinases as Drug Development Targets for Heart Disease Therapy
Pharmaceuticals, 2010 Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease.
Alison L. Müller, Naranjan S. Dhalla
doaj +1 more source
Journal of Pharmacological Sciences, 2007 Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown.
Xiaona Ge, Brad Low, Mei Liang, Jian Fu
doaj +1 more source
Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells [PDF]
, 2007 To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A ...
Scharenberg, Andrew M. +3 more
core +1 more source
Journal of Lipid Research, 2003 Glycosylphosphatidylinositols (GPIs) are the most abundant molecules present in the membranes of the parasitic protozoa Leishmania responsible for multiple forms of leishmaniasis.
Mamta Chawla, Ram A. Vishwakarma
doaj +1 more source
Phosphorylation of protein kinase C by casein kinase‐1 [PDF]
FEBS Letters, 1989 Because phosphorylation of protein kinase C (PKC) may provide a mechanism for regulation of this enzyme, we have examined the ability of two other kinases to phosphorylate PKC. Our results show that casein kinase 1 (CK‐1), but not casein kinase 2 (CK‐2), can phosphorylate PKC in the absence of Ca2+ and phospholipids.
Vila, Jordi +4 more
openaire +2 more sources
Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase [PDF]
, 2013 Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle.
Bastie, Claire C. +6 more
core +1 more source
Protein kinase C and human uterine contractility
BMC Pregnancy and Childbirth, 2007 Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to propose more appropriate and effective
Dallot Emmanuelle +2 more
doaj +1 more source
Journal of Lipid Research, 2001 Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar +5 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Phospholipase C-β 2 interacts with mitogen-activated protein kinase kinase 3
, 2002 Phospholipase C (PLC)-β enzymes (isoenzymes β1–β4) are activated by G protein subunits, leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C.
Barr, A.J. +3 more
core +1 more source