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Membrane Ultrastructure and T Cell Activation [PDF]
Frontiers in Immunology, 2018 The immune system serves as a crucial line of defense from infection and cancer, while also contributing to tissue homeostasis. Communication between immune cells is mediated by small soluble factors called cytokines, and also by direct cellular ...
Johannes Pettmann +4 more
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Frontiers in Immunology, 2022 Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The role of
Clemens Cammann +17 more
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FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab
Frontiers in Immunology, 2023 IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner +4 more
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Cells, 2021 LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez +5 more
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Annual Review of Immunology, 2009 This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals.
Jennifer E, Smith-Garvin +2 more
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Interrogating ligand-receptor interactions using highly sensitive cellular biosensors
Nature Communications, 2023 Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk +10 more
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Frontiers in Immunology, 2022 Toll-like receptors (TLRs) are primary pattern recognition receptors (PRRs), which recognize conserved microbial components. They play important roles in innate immunity but also in the initiation of adaptive immune responses.
Katharina Radakovics +7 more
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BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
Frontiers in Immunology, 2022 The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.
Claire Battin +5 more
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Frontiers in Immunology, 2021 Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas +18 more
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T-Cell Activation: Two for T [PDF]
Current Biology, 1995 T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.
Guerder, Sylvie, Flavell, Richard A.
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